28 (31.5%) had a baseline TTE on file; 5 patients had LVSD prior to arrest and were excluded, leaving a cohort of 84 patients. Thirty-one (36.9%) patients had LVSD on TTE after ROSC, of which 16 (51.6%) had recovery of EF on follow up TTE. The figure shows the timeline of EF...
N. et al. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell 157, 565–579 (2014). Article CAS PubMed PubMed Central Google Scholar Cardoso, A. C. et al. Mitochondrial substrate utilization regulates cardiomyocyte cell cycle progression...
Cardiac arrest is a common and devastating emergency of both the heart and brain. More than 380,000 patients suffer out-of-hospital cardiac arrest annually in the USA. Induced cooling of comatose patients markedly improved neurological and functional out
Mammalian cardiomyocytes exit the cell cycle postnatally due to changes in structure and energy metabolism; partial in vivo reprogramming of adult mammalian cardiomyocytes can increase their proliferation capacity. Fibrosis in the injured heart is both beneficial and detrimental; altering fibrotic tissue com...
Extracorporeal cardiopulmonary resuscitation (ECPR) is emerging as a feasible and effective rescue strategy for prolonged cardiac arrest (CA). However, prolonged total body ischemia and reperfusion can cause microvascular occlusion that prevents organ reperfusion and recovery of function. One hypothesized mec...
When patients remain in PVS/UWS for over 3 months after the cardiac arrest, the condition is considered irreversible and life-sustaining treatment (i.e., artificial hydration and nutrition) may be considered as futile and hence be withdrawn. At present, the chances of recovery after post-anoxic...
Extracorporeal cardiopulmonary resuscitation (ECPR) is emerging as a feasible and effective rescue strategy for prolonged cardiac arrest (CA). However, prolonged total body ischemia and reperfusion can cause microvascular occlusion that prevents organ reperfusion and recovery of function. One hypothesized mec...
36 November 2021 Retrospective cohort study of 718,365 patients who tested positive for COVID Incidence of myocarditis/pericarditis; all‐cause mortality, hospitalization, cardiac arrest, incident HF, incident AF, and acute MI in patients with & without myocarditis/pericarditis 5% developed new ...
N. et al. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell 157, 565–579 (2014). CAS PubMed PubMed Central Google Scholar Nakada, Y. et al. Hypoxia induces heart regeneration in adult mice. Nature 541, 222–227 (2017). CAS ...
Despite cardioplegic arrest, IR-associated cardiodepression is a major problem in heart surgery. We determined the effect of increasing ischemia time on the respiratory chain (RC) function, the inner membrane polarization and Ca2+ homeostasis of rat cardiac subsarcolemmal mitochondria (SSM). Methods...