signaling, and the release of proinflammatory cytokines, ultimately inducing an inflammatory response in cardiomyocytes [28]. These inflammatory responses maintain SASP phenotypes, promoting the progression of cardiovascular diseases. The findings imply that ROS are vital in inducing senescence in the heart ...
Cardiac amyloidosis may manifest primarily or be discovered incidentally in patients with other signs and symptoms of systemic amyloidosis. Delay in diagnosis is common and may lead to a delay in the initiation of the treatment.[4]Cardiac involvement in systemic amyloidosis carries prognostic value and...
catheters) having a plurality of ultrasonic transducers located at their distal end. The configuration of the plurality of ultrasonic transducers may be reversibly changed from a first to a second configuration, where the radial
MCL-1 is a prosurvival B-cell lymphoma 2 family protein that plays a critical role in tumor maintenance and survival and can act as a resistance factor to multiple anticancer therapies. Herein, we describe the generation and characterization of the highl
The T1 mapping procedure is currently being evaluated as a new technique for detection and quantification of global myocardial enhancement, as seen in cardiac amyloidosis. Sensitivities and specificities for detection of cardiac sarcoidosis and amyloidosis can be significantly improved by MRI, especially ...
of the myocardium as diastolic relaxation followed by systolic impairments during progression of the disease. In peripheral sensorimotor neurons, ATTR deposits are causing polyneuropathy, which are, together with cardiomyopathy, the major clinical manifestations of TTR amyloidosis4. Most sporadic and many ...
Gadolinium-based contrast has been shown to accumulate in the myocardium in a number of conditions apart from heart failure, such as arrhythmogenic right ventricular dysplasia, sarcoidosis, and amyloidosis. But in these conditions, delayed enhancement is also thought to be due to the presence of ...
Cardiac Amyloidosis (CA) is a manifestation of a systemic disorder resulting from the deposition of transthyretin (TTR) in the myocardium. This leads to a myriad of manifestations ranging from conduction defects to heart failure. Previously CA was considered a rare disease, but recent advances in ...
of the disease process can allow institution of treatment with pharmacological and non-pharmacological therapy to ameliorate symptoms, retard disease progression and in some cases prolong life by changing the natural course of the disease. An appreciation of the underlying genetics is essential to ...
Prevalence and Post-surgical Outcomes of CARdiac Wild-type TransthyrEtin amyloidoSIs in Elderly Patients With Aortic steNosis Referred for Valvular Replacement. No drug interventions screening Not Available active_not_recruiting NCT00516620 Fruits, Vegetables, and Whole Grains: A Community-based Intervention...