10-12,14 Most surgical pathologists use variations of the 1989 WHO terminology.11 In this system, the terms dysplasia, adenocarcinoma in situ, intramucosal adenocarcinoma, and invasive adenocarcinoma are accepted. Each has a precise meaning when applied to colorectal polyps and appropriate pati...
Additional consideration was to use words translatable to other languages without losing their exact meaning. As a result, the term “noninvasive follicular thyroid neoplasm with papillary-like nuclear features” (NIFTP) was accepted. Diagnostic Nuclear Score To provide simplified and reproducible criteri...
There is simply too much confusion among clinicians with regard to the meaning of this term. The terminology that I favor for neuroendo- crine neoplasia is outlined in Table 1. Under this system, typical carcinoid tumors are designated as well-differentiated neuroendocrine carcinomas, fol- lowed ...
Meaning Among patients with advanced or metastatic esophageal squamous cell carcinoma, an initial treatment strategy of camrelizumab combined with chemotherapy, compared with placebo and chemotherapy, resulted in improved overall survival and progression-free survival. Abstract Importance Standard first-line...
Adjuvant treatment was not altered based on a patient’s response to neoadjuvant ICB meaning that patients with a pretreatment indication for adjuvant (chemo)radiotherapy received such treatment even if an ICB response left them with a pathological stage that did not warrant adjuvant (chemo)...
[11] give a detailed description of 13 locoregional treatment failures after postoperative RT, with only 3 failures “entirely within high-risk PTV60 or PTV66” and 2 multifocal failures not assessed in respect to PTV coverage at all, meaning the remaining 8 failures were at least “marginal”...
Meaning The manageable safety profile and promising response rates observed in this study support further investigation of nivolumab plus ipilimumab as a treatment option for this patient population. Abstract Importance Most patients with hepatocellular carcinoma (HCC) are diagnosed with advanced disease not...
resulting in inconsistency in the meaning of the pathologic T, N, and M categories across different patients resected during different time periods. In addition, the pathology reports in TCGA-LIHC came from different institutions with wide variation in the reporting of pathologic features. Therefore,...
Meaning Monotherapy with ipilimumab had minimal clinical activity but increased peripheral lymphocyte activation markers; failure to note these changes in tumors may explain the lack of clinical activity. Abstract Importance Based on evidence of human papillomavirus (HPV)–induced immune evasion, immunotherap...
Meaning The findings of this trial indicate that the addition of berzosertib does not add to the efficacy of cisplatin and gemcitabine chemotherapy in patients with metastatic urothelial cancer, likely because of added hematologic toxic effects with the combination resulting in substantial dose reductions...