For several decades, patients with neuroendocrine tumors and carcinoid syndrome have been treated with somatostatin analogues as the first-line treatment. While these agents provide significant relief from carcinoid syndrome symptoms, there is inevitable clinical progression, and new therapeutic interventions ...
本周,致力于研发精准新药用于治疗严重慢性疾病的生物制药公司Lexicon Pharmaceuticals宣布,美国FDA已接受了telotristat etiprate新药申请的优先审评。若通过,telotristat etiprate将是首个被批准用于类癌综合症(carcinoid syndrome)的口服治疗药物。 类癌综合症是一种影响数以千计的神经内分泌瘤(neuroendocrine tumors, NET)...
参考文献 Lexicon Pharma Announces FDA Priority Review Of New Drug Application For Telotristat Etiprate For The Treatment Of Carcinoid Syndrome Lexicon Announces FDA Priority Review Of New Drug Application For Telotristat Etiprate For The Treatment Of Carcinoid Syndrome Lexicon Pharmaceuticals 官网...
The global carcinoid syndrome diarrhea treatment market is highly concentrated due to the presence of key players. A large number of manufacturers hold a major share in their respective region. Key developments such as product launch and approval is by industry players are likely to fuel...
A phase 3 randomised double-blind placebo-control trial, Evaluating Lanreotide Efficacy and safety as a Carcinoid-syndrome Treatment (ELECT), included a total of 115 patients. The primary end-point of this study was the mean percentage of days with rescue octreotide use. The control arm received...
Long-Term Management of the Carcinoid Syndrome Treatment with octreotide alone and in combination with alpha-interferonLong-term results of treatment of malignant carcinoid syndrome with prolonged release Lanreotide (Somatuline Autogel)Motor Dysfunction of the Small Bowel and Colon in Patients with the ...
Approved for adults by the FDA in 2017 for the treatment of diarrhea associated with carcinoid syndrome that isn't adequately controlled by SSA therapy alone Interferons Natural substances that activate the body's immune system and slow the growth of some tumor cells ...
SOMATULINE DEPOT is a prescription medicine used in adults for: the treatment of a type of cancer known as neuroendocrine tumors, from the gastrointestinal tract or the pancreas (GEP-NETs) that has spread or cannot be removed by surgery; and the treatment of carcinoid syndrome to reduce the ne...
Included in this report is a brief summary of the carcinoid syndrome based on a case history of a patient followed from diagnosis to death and post-mortem examination. The current status of treatment of this condition is discussed. Get PDF (538K) More content like this Find more content: ...
The drug was tested in a pivotal phase 3 trial, known as TELESTAR. The trial was conducted in 135 patients with carcinoid syndrome that was not adequately controlled on treatment with long- acting somatostatin analogues (SSA), which is the current standard of care. ...