EXAMPLE:An L-seryl-trans-4-aminomethylcyclohexanecarboxylic acid derivative. USE:Useful as a medicine having anticomplementary action, carcinostatic action, antiulcer action and antithrombotic action. PROCESS:An N-protected amino acid is reacted with a chloride, e.g. SOCl<2> or PCl5, in an ...
EXAMPLE:An L-seryl-trans-4-aminomethylcyclohexanecarboxylic acid derivative. USE:Useful as a medicine having anticomplementary action, carcinostatic action, antiulcer action and antithrombotic action. PROCESS:An N-protected amino acid is reacted with a chloride, e.g. SOCl<2> or PCl5, in an ...
In one example, an ethylene-methacrylyl chloride copolymer (obtained by reacting the corresponding acid polymer with PCl5) is further reacted by heating with KHF2 to convert half the acid chloride groups to acid fluoride groups. In another example, a (chlorinated ethylene)-methacrylic acid ...
PCl5; the resulting chloro-carboxylic acid chloride being reacted with a primary or secondary amine.ALSO:A stabilized composition comprises a polymer and/or a copolymer of an olefinically unsaturated hydrocarbon and as a stabilizing additive a phosphorus-containing carboxylic acid amide of the formula...
In examples: (1) 1-phenyl-cyclopentyl-1-carboxylic acid chloride is reacted with diethylamino-ethanol in ether solution. Instead of the above acid, there may also be used substituted in the phenyl nucleus. Substituents mentioned include methoxy, ethoxy, chloro and bromo; (2) 1-phenyl-...
General procedure for the synthesis of 7a,b To a solution of 3,4,5-trimethoxylbenzoic acid or 3,4-dimethoxycinnamic acid (4 mmol) in ether (20 mL) was added PCl5 (20 mL) in one portion. The reaction mixture was heated to reflux for about 4 hours and then cooled to room temperature...