A method for biosynthesis of polymer precursors, including, adipic acid, 1,6-hexanediol, 6-hydroxyhexanoic and 6-aminocaproic acids from carboxylic acids is provided. A method for biosynthesis of adipic acid from six-carbon dicarboxylic acids having a, 尾-enoate reductase activity by treatment with...
Azetidine-2-carboxylic acid (AZE) is a long-known plant metabolite. Recently, AZE synthases have been identified in bacterial natural product pathways involving non-ribosomal peptide synthetases. AZE synthases catalyse the intramolecular 4-exo-tet cyclis
Thus, the ESI–MS and 1H NMR spectral data confirmed the potential AMC as 5-butyl-2-pyridine carboxylic acid with a molecular formula of C10H13NO2 (Supplementary Fig. S4e). Phytochemical screening, solubility and thermo-stability of the compound Phytochemical screening of the pure fraction ...
With the optimal conditions in hand, we explored the substrate scope of carboxylic acids. As can be seen in Fig.2, this Umpolung amidation has a satisfactory functional group compatibility and a broad carboxylic acid substrate scope. A series of structurally diverse carboxylic acids (1a-1rr) are...
An interesting dehydration of an optically active β-hydroxy acid under retention is shown in Scheme 41 <69TL1047, 87HCA1320>. A similar aldol addition cyclization tandem process has been devised using acyl iron intermediates (Scheme 42) <91SL781>. Sign in to download full-size image Scheme ...
process efficiency RE: recovery RSD: relative standard deviation SA: salicylic acid SAM: S-adenosyl-l-methionine SD: standard deviation SPE: solid-phase extraction tZ: trans-zeatin tZR: trans-zeatin riboside UHPLC: Ultra High Performance Liquid Chromatography ...
93 The pathway shares the first step with the cyclohexanecarboxylic acid biosynthetic pathway, anti elimination of H6R from (54),94,95 but diverges at the stage of (57). Both (57) and (68) were incorporated into (65), implicating (67a) or its C-1 epimer (67b) as a likely ...
This process, single electron oxidation followed by ring cleavage, is of high biological significance. For instance, ethylene, which plays a major role as a phytohormone, is produced in plants from 1-aminocyclopropanecarboxylic acid (ACC). This transformation is catalysed by the enzyme...
Development of a Plasmid-Free Biosynthetic Pathway for Enhanced Muconic Acid Production in Pseudomonas chlororaphis HT66. Muconic acid is a platform chemical and an important intermediate in the degradation process of a series of aromatic compounds. Herein, a plasmid-free synt... Songwei,Wang,Muhamma...
The process of present invention includes the production of dimer of phenazine-1-carboxylic acid natural product by a fluorescent pseudomonad bacterium. The ingredient of “water-based semi-solid media” for initial growth of the bacterium is preferably about 2 to 30 g/L of protease peptone, mos...