PURPOSE:The reaction between thionyl chloride and a carboxylic acid is effected in the presence of a tertiary amine in specific amount based on the carboxylic acid to produce the titled compound with no formation of by-produce such as sulfenylchloride under mild conditions in high yield. ...
Notes: The reaction is actually an equilibrium. The alcohol is generally used as solvent so is present in large excess. Many different acids can be used; it’s common to see just “H+”, although H2SO4 (sulfuric acid) and TsOH (tosic acid) are also often use...
aAcid chlorides are most often prepared by the reaction of a carboxylic acid with either thionyl chloride or phosphorus pentachloride in much the same way that alkyl chlorides are prepared from alcohols 酸氯化物由羧酸的反应在相似情况下经常准备与亚硫酰氯或磷五氯化物烷基氯化物从酒精准备 [translate...
acid chloride. This should be difficult to do because if you remember, acid chloride is the most reactive acyl compound. It's all the way over here. To get carboxylic acid all the way over here, I'm going to need a strong reagent. That's exactly what we're going to u...
Fig. 9. The three-component reaction of one equivalent of racemic hydroxy acid, optically pure R-α-methylbenzylamine, and 2-formylphenylboronic acid yielding diastereomeric iminoboronate esters (R,R) and (R,S).Reproduced from S.R. Chaudhari, N. Suryaprakash, Three-component chiral derivatizing...
The B terminals are expected to exhibit high reactivity due to the high flexibility derived from the ether bonds and less steric hindrance; therefore, higher molecular weights can be expected. Moreover, the B terminals can be utilized as a weak-acid terminal without any end- capping reaction. ...
can be produced by dissolving 3-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-propenic acid in dry benzene, dropping thionyl chloride to the solution at room temperature, dropping dry DMF, stirring the reaction solution for 6hr in a light-shielded state, distilling out thionyl chloride under ...
the starting material used in the present case, the starting materials are particularly readily accessible and inexpensive cinnamic acid derivatives whose reaction with thionyl chloride yields the benzothiophenecarboxamides of the formula (IIb) required in a smooth reaction (cf., for example, DE 3 832...
-phenylcaproicacid Chapter143=> IUPACNames Remove-efromalkane(oralkene)name,add-oicacid.Thecarbonofthecarboxylgroupis#1.ClOCH3CH2CHCOH PhCHC HCOOH 2-chlorobutanoicacidtrans-3-phenyl-2-propenoicacid(cinnamicacid)=> Chapter144 NamingCyclicAcids Cycloalkanesbondedto-COOHarenamedas...
Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives are prepared by reacting the heterocyclic compounds with cyclohexanecarboxylic acid derivatives which are substituted by