Carbon–carbon (C–C) bonds form the backbone of many important molecules, including polymers, dyes and pharmaceutical agents. The development of new methods to create these essential connections in a rapid and practical fashion has been the focus of numerous organic chemists. This endeavour relies ...
The activation of carbon-carbon (C-C) bonds is an effective strategy in building functional molecules. The C-C bond activation is typically accomplished via metal catalysis, with which high levels of enantioselectivity are difficult to achieve due to high reactivity of metal catalysts and the metal...
enzymes functionalize diverse substrates containing benzylic, allylic or α-amino C–H bonds with high turnover and excellent selectivity. Furthermore, they have enabled the development of concise routes to several natural products. The use of the native iron-haem cofactor of these enzymes to mediate...
The coupling of one‐carbon (C1) fragments to form carbon–carbon bonds has been studied on a Cu(110) surface. In these studies, methyl (CH3) and methylene (CH2) groups have been generated on Cu(110) by the dissociative adsorption of CH3I and CH2I2, respectively. Formation of CH3(a) ...
These molecules burnmore cleanly than gasoline, in partbecausetheyhave fewer, if any, carbon-carbonbondsand thehydrocarbons theydoemit are lesslikely to generate ozone. The combustion oflargermolecules,which havemultiple carbon-carbon bonds involves a more complex series of reactions. These reactions ...
Two C-C bonds form, and the redox non-innocence of the resulting pyridine-imines may be critical to formation of a third C-C bond via dinuclear di-imine oxidative coupling. Unique metal-metal bonds are a consequence of the chelation. 展开 ...
Formation of carbon–carbon bonds α to the carbonyl group is dominated by the chemistry of enolates and their derivatives. Despite the diverse reactivity of this class of nucleophiles—including aldol and Mannich-type additions, SN2 and SN1 reactions with alkylating agents, and transition metal-cat...
Methods for the formation of C-C bonds in heterocycles which occur via Ni- and Pd-catalyzed cross-coupling, alkenylation and alkynylation reactions are summarized. The influence of the organometallic-component and the nature of the catalyst on the efficiency of cross-coupling reactions are analyzed,...
Formation of Carbon—Carbon Bonds Abstract Despite the fundamental importance of carbon—carbon bond formation in organic synthesis, there are only a very limited number of “classical” methods available which proceed selectively, in high yield, under mild conditions. However, transition-metal-mediated...
A simple VB analysis is used to illustrate that the greater stability of geminally disubstituted ethanes and ethylenes compared to their vicinally substituted counterparts is due to the strength of the central C-C bond and not to the stability of the radical and carbene fragments that compose ...