Pharmacologic class: Dopamine agonist Therapeutic class: Antiparkinsonian Pregnancy risk category C Action After conversion to dopamine in CNS, levodopa acts as a neurotransmitter, relieving symptoms of Parkinson's disease. Carbidopa prevents destruction of levodopa, making more levodopa available to be de...
Alternative Names: Accordion pill carbidopa/levodopa; Accordion Pill levodopa/carbidopa; Accordion Pillcarbidopa/levodopa; AP 09004; AP-CD/LD; AP-CDLD; Carbidopa/levodopa gastric retentive - Indaptus Therapeutics; Levodopa/carbidopa controlled release - Indaptus Therapeutics; Levodopa/carbidopa gastric reten...
-Optimum dose should be determined by careful titration; therapy should be individualized and adjusted according to the desired therapeutic response. Use: For the treatment of Parkinson's disease:--As a substitute for equivalent strengths of each component;--Or to replace carbidopa/levodopa therapy ...
When levodopa is administered orally, it is rapidly decarboxylated to dopamine in extracerebral tissues so that only a small portion of a given dose is transported unchanged to the central nervous system. For this reason, large doses of levodopa are required for adequate therapeutic effect, and ...
When levodopa is administered orally, it is rapidly decarboxylated to dopamine in extracerebral tissues so that only a small portion of a given dose is transported unchanged to the central nervous system. For this reason, large doses of levodopa are required for adequate therapeutic effect, and ...
Following initiation of therapy, doses and dosing intervals may be increased or decreased depending upon therapeutic response. Most patients have been adequately treated with doses of carbidopa and levodopa extended-release tablets that provide 400 mg to 1600 mg of levodopa per day, administered as ...
Dosage of LODOSYN may be adjusted by adding or omitting one-half or one tablet a day. Because both therapeutic and adverse responses occur more rapidly with combined therapy than when only levodopa is given, patients should be monitored closely during the dose adjustment period. Specifically, invo...
Epstein, MichaelJohnson, DavidHawes, RobertVanagunas, ArvydasSchmulewitz, NathanZadikoff, CindyGossen, RodRobieson, WeiningEaton, SusanDubow, Jordan
Experience with LCE has established that improved levodopa pharmacokinetics achieved with dual-enzyme inhibition are translated into improved clinical efficacy, including the possibility of reducing total levodopa dosage with no loss of therapeutic effect. The ease and tolerability of switching to LCE has ...
Individualize maintenance dosage according to desired therapeutic response. Patients should receive at least 70–100 mg of carbidopa daily during maintenance therapy.Use of combination preparations containing a 1:10 ratio of carbidopa to levodopa may not provide an adequate amount of carbidopa. If a ...