A new N-glucuronide metabolite of carbamazepineAn N-glucuronide metabolite of carbamazepine was identified in the bile of the isolated perfused rat liver by means of permethylation, gas chromatography and mass spectrometry.doi:10.1007/BF01933954J E BauerN GerberR K LynnR G SmithR M Thompson...
Carbamazepine N-Glucuronide 英文别名: Carbamazepine N-Glucuronide 中文名: CARBAMAZEPINE N-GLUCURONIDE 中文别名: CARBAMAZEPINE N-GLUCURONIDE CBNumber: CB08025203 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商1 CARBAMAZEPINE N-GLUCURONIDE化学性质 ...
Other important biotransformation pathways for carbamazepine lead to various monohydroxylated compounds, as well as to the N-glucuronide of carbamazepine produced by UGT2B7. After administration of a single oral dose of 400 mg carbamazepine, 72% is excreted in the urine and 28% in the faeces. ...
The history of the development of carbamazepine was outlined in an earlier volume in this series (Schmutz1985). By that time, the drug had already been in clinical use for two decades and was a well established antiepileptic agent, with certain other uses in human medicine. Its animal pharmaco...
Carbamazepine (CBZ) undergoes biotransformation by CYP3A4 and CYP2C8, and glucuronide conjugation. There has been no clear demonstration to reveal the role... KA Kim,SO Oh,PW Park,... - 《European Journal of Clinical Pharmacology》 被引量: 68发表: 2005年 Effect of Multiple Dose Omeprazole...
10,11-Dihydro-10-hydroxy Carbamazepine O-β-D-Glucuronide (mixture of diastereomers) CAS Number 144407-84-1 Category Glucuronides, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals Mol. Formula C21H22N2O8 Mol. Weight 430.41 Qty 1 1mg Qty 2 10mg Appearance N/A Applicat...
中文名称:CARBAMAZEPINE N-GLUCURONIDE 中文同义词:CARBAMAZEPINE N-GLUCURONIDE 英文名称:Carbamazepine N-Glucuronide 英文同义词:Carbamazepine N-Glucuronide CAS号: 分子式: 分子量:0 EINECS号: 信息错误报告 您的Email: 按国家浏览Carbamazepine N-Glucuronide国外供应商中国供应商 ...
Among metabolites, CBZ N-glucuronide (CBZ-Glu, Phase II metabolite) was discharged into sewage system together with Phase I metabolites such as 2-hydroxycarbamazepine (2-OH-CBZ), 3-hydroxycarbamazepine (3-OH-CBZ), 10-hydroxycarbamazepine (10-OH-CBZ), 10,11-Dihydroxycarbamazepine (DiOH-CBZ),...
Among metabolites, CBZ N-glucuronide (CBZ-Glu, Phase II metabolite) was discharged into sewage system together with Phase I metabolites such as 2-hydroxycarbamazepine (2-OH-CBZ), 3-hydroxycarbamazepine (3-OH-CBZ), 10-hydroxycarbamazepine (10-OH-CBZ), 10,11-Dihydroxycarbamazepine (DiOH-CBZ),...
(Life Sci. 1978; 23:83-7.) To obtain a standard for CBZ-glucuronide, it was isolated from the urine of patients on CBZ monotherapy using a procedure similar to that previously published. (Sinz M W, Remmel R P. Analysis of lamotrigine and lamotrigine 2-N-glucuronide in guinea pig blood...