论文标题为“Uncovering the mode of action of engineered T cells in patient cancer organoids”。
In the most recent clinical trials, CAR T-cell therapy is typically administered after multiple rounds of prior treatments for patients with R/R MM. However, the efficacy of successive therapies tends to diminish, with decreasing response rate, shallower depth of response, and shorter times to di...
CAR T-cell therapies combine cellular therapy, gene therapy and immune therapy to use a patient’s own T-cells to fight cancers. We help our clients evaluate their novel medicines/molecules for their mode of action
We use retroviral vectors (RV) (Fig.1a) to engineer murine T cells. After validating inducible NAP expression (Supplementary Fig.1), we evaluated the efficacy of CAR(NAP) T cells to target endogenously expressed murine CD19 and disialoganglioside (GD2) in two immunocompetent, syngeneic mouse ...
Proposed mode of action of CAR(NAP)-T cell therapy. CAR(NAP)-T cells are CAR-T cells armed with NAP, an immune activator derived from H. pylori.70 Copyright 2022, the author(s). Exogenous enzymes also play an important role in the destruction of physical barriers. In the work of Dott...
15 Engineered IL23 functions predominantly through an autocrine mode of action. (a)ΔCD19-Td cells were rested or activated with αCD3 and αCD28 Abs for 7 days with or without 50 ng/mL recombinant human IL23 (rhIL23). Cell number were numerated by beads counting. Data shown as ...
Based on this phase 1 study, phase 2 patient enrollment will be commenced in Mar 2022 to evaluate the response rate, duration of response of CRC01 as well as safety. In addition, various biomarker studies are planned to investigate the differential mode of action of Anbal-cel during phase 2...
The pace of innovation of multiple myeloma therapy in recent years is remarkable with the advent of monoclonal antibodies and the approval of novel agents with new mechanisms of action. Emerging therapies are on the horizon for clinical approval with sig
3a~b). Further analysis of the mean log2FC of cytokines revealed a distinct cytokine kinetic mode of Group1 from that of Group2 (Fig. 3c~d). The patients in Group1 displayed a higher peak level of CC3, CC4, and CC5 cytokines, as well as the whole, as compared with Group2. ...
However, due to their mode of action, these treatments can result in delayed responses or in inflammatory events that may hamper interpretation of metabolic imaging. Lugano criteria, relying on the Deauville score, are useful, but it is crucial to be aware of the interpretation pitfalls and to ...