Inspiringly, these challenges have failed to hold back the progress being made by studies focusing on the application of CAR-T in solid tumors. In addition, a growing number of promising coping strategies have gradually emerged. Both the problems and solutions associated with the development and ...
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In solid tumors, usually, it is more common to recognize a tumor-associated antigen (TAA) wherever the expression of markers, such as CEA, ERBB2, EGFR, GD2, mesothelin, MUC1, and PSMA, is increased on cancer cells. It should be noted that these markers are also expressed at a low ...
[2] Urvi P, John A, Bipin N et al. CAR T cell therapy in solid tumors: A review of current clinical trials. eJHaem. 2022;3(Suppl. 1):24–31. [3] Barros LRC, Couto SCF, Cardoso F et al. Systematic Review of Available CAR-T Cell Trials...
[1] Repurposing chimeric antigen receptor regulatory T cells for treating cancer. Retrieved from https://www.abstractsonline.com/pp8/#!/20272/presentation/10562 [2]Weaponizing CAR T-cells to attack PD-L1 presenting cells in solid tumors.Retrieved from...
McConaghie, A. ASCO: AstraZeneca Achieves Eye-Catching Solid Tumor Results With 'Armored' CAR-T. Scrip. 06. 06. 2024. Guzman, G. et al. CAR-T Therapies in Solid Tumors: Opportunities and Challenges. Curr Oncol Rep. 2023. 25, 479-489. ...
J. Engineering strategies to overcome the current roadblocks in CAR T cell therapy. Nat. Rev. Clin. Oncol. 17, 147–167 (2020). PubMed Google Scholar Wagner, J., Wickman, E., DeRenzo, C. & Gottschalk, S. CAR T cell therapy for solid tumors: bright future or dark reality? Mol....
[1] 、Marofi F, et al. CAR T cells in solid tumors: challenges and opportunities. Stem Cell Res Ther. 2021;12(1):81. [2]、 The Lancet Oncology. CAR T-cell therapy for solid tumours. Lancet Oncol. 2021;22(7):893. [4]、 Qi C, et al. Claudin18.2-specific CAR T cells in gas...
今年4月,Science Translational Medicine杂志发表的一篇题为“Oncolytic virus–mediated expansion of dual-specific CAR T cells improves efficacy against solid tumors in mice”的论文。美国梅奥医学中心(Mayo Clinic)团队利用双特异性CAR-T细胞成功递送了水泡性口炎病毒和呼肠孤病毒。 装载OV的CAR-T细胞疗法通过静脉...
2022年4月8日,斯坦福大学的研究人员在Science Advances期刊发表了题为: Delivery of CAR-T cells in a transient injectable stimulatory hydrogel niche improves treatment of solid tumors 的研究论文。 该研究开发了一种简单而高效的CAR-T递送方法:将CAR-T细胞和细胞因子添加到特制水凝胶中,这种水凝胶在体内提供了...