对于并发下腔静脉癌栓的患者,治疗选择有限,预后很差。 2015年5月,国内知名的癌症中心启动了首个针对GPC3(Glypican-3)蛋白的CAR T细胞疗法治疗晚期肝细胞癌的临床研究,这项研究数据曾在2020年发表在国际重磅肿瘤学期刊《Clin Cancer Res》上。详情点击:骄傲!中国研发全球首个靶向GPC3的CAR-T疗法,成功挽救晚期癌症患...
Dr. Ho: CAR-T cell therapy uses an antibody as a guide or sensor to locate the immune cells—in this case, T-cells—to the tumors then kill tumors using T-cell signaling. So therefore, CAR-T cells use both antibody specifi...
超越癌症，CAR-T免疫细胞具有无限的潜力 CAR-T疗法的基础原理是将 T 细胞的效力与抗体的特异性结合起来，以精确杀死患病细胞。如下图所示，CAR 的组件包括构成单链可变片段 (scFv) 的可变轻链 (VL) 和可变重链 (VH)，而这些组件就相当于一个“定位导航”一样帮助T细胞这个“武器”对肿瘤细胞进行“精准打击”，...
尽管在血液肿瘤中取得了巨大成功,但将其应用于实体瘤,特别是如胶质母细胞瘤这样复杂的脑癌,需要克服更多的科学和技术难题。(3月13日Nature“Deadly brain cancer shrinks after CAR-T therapy — but for how long is unclear”) 胶质母细胞瘤的挑战 ...
[1]Dorff T B,et al. PSCA-CAR T cell therapy in metastatic castration-resistant prostate cancer: a phase 1 trial[J]. Nature Medicine, 2024: 1-9.https://www.nature.com/articles/s41591-024-02979-8 [2]https://www.oncologypipeline.com/apexonco/asco-2024-astrazenecas-gpc3-secret-sauce [...
[4]Liu H, Xu Y, Xiang J, et al. Targeting Alpha-Fetoprotein (AFP)-MHC Complex with CAR T-Cell Therapy for Liver Cancer. Clin Cancer Res. 2017;23(2):478-488. https://pubmed.ncbi.nlm.nih.gov/27535982/ [5]Pievani A, Borleri G, Pende D, et al. Dual-functional capability of ...
are inventors on several patents issued and pending in the field of CAR T cell therapy for cancer, which are assigned to the University of Pennsylvania. Under the University of Pennsylvania’s policies, J.J.M., D.J.P. Jr and M.C.M. either currently, or may in the future, receive ...
2#Miriam Y. Kimet al. A long-acting interleukin-7, rhIL-7-hyFc, enhances CAR T cell expansion, persistence, and anti-tumor activity. Nature Communications. (2022) 3#CAR-T countdown: NeoImmuneTech drug could reduce number of cells needed for cancer therapy fivefold (来源:FIERCE Biotech)...
[4]Zhou Y,et al.Therapeutic potential of tumor treating fields for malignant brain tumors[J].Cancer Reports, 2023, 6(5):e1813. https://onlinelibrary.wiley.com/doi/full/10.1002/cnr2.1813 [5]Nakagawa Y,et al.Boron neutron capture therapy: clinical brain tumor studies[J]. Journal of neuro...
[2]Qi C,et al.CT041 CAR T cell therapy for Claudin18.2-positive linkstatic pancreatic cancer. J Hematol Oncol.2023 Sep 9;16(1):102. https://jhoonline.biomedcentral.com/articles/10.1186/s13045-023-01491-9 [3]https://www.pennmedicine.org/news/news-releases/2024/march/dual-target-cell-...