Abstract 5248: Novel costimulatory domain improves CAR-monocyte activity against tumorsdoi:10.1158/1538-7445.AM2024-5248Myeloid cells, unlike other immune cells such as T cells or NK cells, are known residents i
In humanized mice with high leukemia burden, CAR T cell–mediated clearance of cancer triggered high fever and elevated IL-6 levels, which are hallmarks of CRS. Human monocytes were the major source of IL-1 and IL-6 during CRS. Accordingly, the syndrome was prevented by monocyte depletion ...
However, the first barrier to overcome is effective infiltration of engineered CAR-M into the tumor from the periphery. We have demonstrated that our engineered CAR-Monocyte drug product can successfully home to the targeted tumor specifically, from the periphery. Subsequent in situ differentiation of...
Cariporide inhibits high glucose-mediated adhesion of monocyte–endothelial cell and expression of intercellular adhesion molecule-1 . Life Sci 79 : 1399 – 1404 .Wang S X,Sun X Y,Zhang X H. Cariporide inhibits high glucose-mediated adhesion of monocyte-endothelial cell and expression of ...
we further demonstrate that antibody-mediated neutralization or TALEN-mediated genetic inactivation of GMCSF in CAR T-cells drastically decreases available GMCSF and abolishes macrophage-dependent secretion of CRS biomarkers, including monocyte chemoattractant protein 1 (MCP-1), interleukin 6 (IL-6), and...
Aims To investigate the potential prognostic impact of the lymphocyte-monocyte ratio (LMR) in a large European cohort of patients with localised upper urinary tract urothelial carcinoma (UTUC). The LMR as an indicator of systemic inflammatory response has been shown to represent a potential ...
Pretreatment lymphocyte-monocyte ratio as a potential prognostic factor in a cohort of patients with upper tract urothelial carcinoma. J Clin Pathol 2015;68:351-5.Hutterer GC, Sobolev N, Ehrlich GC, et al. Pretreatment lymphocyte- monocyte ratio as a potential prognostic factor in a cohort of ...
and CD16 + Monocyte-Derived Dendritic Cells in Patients with Metastatic Renal Cell Carcinoma Treated with Dendritic Cell Vaccines[J] . J. Carlos Arroyo,Fernando Gabilondo,Luis Llorente,Marco A. Meraz-Ríos,Carmen Sánchez-Torres.Journal of Clinical Immunology . 2004 (1)...