2024年2月22日,德国埃尔朗根-纽伦堡大学(FAU)的Georg Schett教授团队在《新英格兰医学杂志》(NEJM)上发表了题为:CD19 CAR T-Cell Therapy in Autoimmune Disease — A Case Series with Follow-up的研究论文【1】。 该论文报道了15名自身免疫病患者(8名系统性红斑狼疮患者、4名系统性硬化症患者和3名特发性炎...
CAR-T细胞疗法的全称是chimeric antigen receptor T cell therapy,即嵌合抗原受体T细胞疗法,原理是应用患者自身的T淋巴细胞,经过实验室重新改造,装载上具有识别肿瘤抗原的受体及共刺激分子,体外扩增后再次回输入患者体内,从而识别并攻击自身的肿瘤细胞。2014年,CAR-T细胞治疗已在急性淋巴细胞白血病(ALL)中取得显著疗效,...
经CAR-T治愈的幸运小女孩Emily从12年接受治疗后,一直有安全性随访,她每年也会拍一张照片po到社交网站上。 相关链接及参考: Novartis CAR-T cell therapy CTL019 unanimously (10-0) recommended for approval by FDA advisory committee to treat pediatric, young adult r/r B-cell ALL | Novartiswww.nova...
参考资料: https://www.fda.gov/vaccines-blood-biologics/safety-availability-biologics/fda-investigating-serious-risk-t-cell-malignancy-following-bcma-directed-or-cd19-directed-autologous https://www.fiercepharma.com/pharma/fda-investigates-serious-risk-secondary-cancer-following-car-t-therapy-treatment h...
[1] CAR T cell therapies raise hopes — and questions — for lupus and autoimmune disease,Retrieved Oct 16, 2023, from https://www.nature.com/articles/d41573-023-00166-x [2] Mackensen, A., Müller, F., Mougiakakos, D. et al. Anti-CD19 CAR T cell therapy for refractory systemic...
1.https://www.thedp.com/article/2024/03/penn-emily-whitehead-car-t-cell-therapy-carl-june 2.https://www.onclive.com/view/fda-clears-investigational-new-drug-application-for-tcr-nk-cell-therapy-in-multiple-myeloma ...
for the treatment of metastatic breast cancers [4]2024 AACR: A phase 1 dose escalation study of a novel coupled CAR T cell therapy, GCC19CART, for patients with metastatic colorectal cancer 声明：本文仅作健康科普，不能替代医院的检查和治疗。如有相关疾病，请及时去正规医疗机构就诊，谨遵医嘱。
近期,Cancer Treatment and Research Communications杂志发布了一篇由高博临床研究策略研究院撰写的关于通用型嵌合抗原受体T细胞(CAR-T)疗法研究现状与技术分析的综述文章Universal chimeric antigen receptor T cell therapy — The future of cell therapy: A review providing clinical evidence,从通用型CAR-T细胞疗法的起...
▲图1 CAR-T细胞治疗的流程 图是在美国南卡罗来纳州医科大学（Medical University of South Carolina）网站（Boston Children's Hospital, https://medicine.musc.edu/departments/surgery/news-and-announcements/2021/june/car-t-cell-therapy-research）和波士顿儿童医院网站（https://answers.childrenshospital.org/...
Inc.) had acquired the Cell Design Labs in order to enhance their footprint in CAR-T cell therapy treatment and other different cell therapies market. Cell Design Labs is highly focused on the research and development of the immunotherapies which is used for the treatment of cancer. This acqui...