Scientist at the University of Tennessee Health Science Center have shown that depleting harmful B cells with CAR-T cells could be a promising strategy to treat lupus. (Nephron/Wikimedia Commons) 一波未平,一波又起,CAR-T疗法进攻实体瘤的声波还未平息【前沿进展】《自然》 | 唤醒沉睡的CAR-T细胞,这...
CAR-T细胞疗法拯救一名快速进展的系统性红斑狼疮的15岁少女，已恢复生活 4月17日，《柳叶刀》（The Lancet）发表一篇名为“CAR T-cell therapyrescues adolescent withrapidly progressive lupus nephritis from haemodialysis”的文章，文章报告了一例15岁女性严重和快速进展的系统性红斑狼疮患者使用CD19 CAR-T细胞治疗后...
4.Wang W, He S, Zhang W, et al. BCMA-CD19 compound CAR T cells for systemic lupus erythematosus: a phase 1 open-label clinical trial. Ann Rheum Dis. Published online May 30, 2024. 点开下方图片,可关注、查看...
[2] Dimitrios Mougiakakos, M.D. Gerhard Krönke, et al. M.D.CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus. N Engl J Med 2021;385:567-569 [3] Mackensen, Müller, Mougiakakos. et al. Anti-CD19 CAR T ce...
早在2021年8月5日,德国埃尔朗根-纽伦堡大学(FAU)风湿病学和免疫学系主任 Georg Schett 教授等人在《新英格兰医学杂志》(NEJM)上发表了题为:CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus 的临床研究论文。 研究团队对一名患有严重系统性红斑狼疮的20岁女性患者进行了 CAR-T细胞治疗,该疗法...
In June 2023, Uresa A. (who was 15 years old at the time) received CAR-T cells at Universitätsklinikum Erlangen. The treatment was the last resort to slow down systemic lupus erythematosus (SLE), which is a serious autoimmune disease that was attackin
4、CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus - PubMed 免责声明 :本文所含的信息来源于文中可靠信源,仅供读者一般参考之用,不应作为决策依据,DrG的雍熙路对因使用本文内容而造成的一切损失,不承担任何责任。部分图片来源于网络,如涉及版权问题,敬请联系我们以便采相应处理举...
[4]Wang W, He S, Zhang W, Zhang H, DeStefano VM, Wada M, Pinz K, Deener G, Shah D, Hagag N, Wang M, Hong M, Zeng R, Lan T, Ma Y, Li F, Liang Y, Guo Z, Zou C, Wang M, Ding L, Ma Y, Yuan Y. BCMA-CD19 compound CAR T cells for systemic lupus erythematosus: ...
3. CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus | New England Journal of Medicine (nejm.org) 4. CAR T-cell therapy rescues adolescent with rapidly progressive lupus nephritis from haemodialysis - The Lancet
2021年8月5日,德国埃尔朗根-纽伦堡大学(FAU)风湿病学和免疫学系主任Georg Schett教授等人在《新英格兰医学杂志》(NEJM)上发表了题为:CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus的临床研究论文。该患者也成为了世界上首个接受 CAR-T 细胞治疗的系统性红斑狼疮患者。虽然只是一名患者,但这...