导读嵌合抗原受体T细胞（Chimeric Antigen Receptor T-cell，CAR-T）疗法是一种新兴的细胞免疫治疗，通过基因工程改造T细胞，使其在细胞表面表达嵌合抗原受体（Chimeric Antigen Receptor T-cell，CAR）。这种受体赋予T细胞识别特定靶细胞表面抗原的能力，并能够对这些表达抗原的细胞介导特异性的细胞毒性反应。近年来，CAR-T...
这种BCMA重定向纳米抗体CAR-T产品在R/R MM患者中表现出令人鼓舞的临床结果,这表明纳米抗体CAR-T产品在临床上可以与传统的基于单链抗体的CAR-T产品一样有效且耐受性良好,为基于纳米抗体的CAR-T细胞疗法展示出光明的前景。 参考文献: 1. Nanobody-based CAR-T cells for cancerimmunotherapy. Biomark Res. 2022; ...
如果您也想寻求CAR-T或国内外其他抗癌新技术(如TIL、TCR-T、NK细胞、益生菌)的帮助,可将出院小结、治疗经历、完整的病理报告等资料,提交至全球肿瘤医生网医学部(400-666-7998),进行初步评估,或申请国内外抗癌专家会诊。 参考资料 ...
2. Muthuvel M, Srinivasan H, Louis L et al. Engineering off-the-shelf universal CAR T cells: A silver lining in the cloud. Cytokine. 2022 Aug;156:155920. 3. Abou-El-Enein M, Elsallab M, Feldman SA et al. Scalable Manufacturing of ...
2020 年,王英晓团队在 Science Advances 上发表了题为Engineering light-controllable CAR T cells for cancer immunotherapy 的论文,首次开发了一种光诱导核易位和二聚化 (LINTAD) 系统,用于基因调控以控制 CAR T 细胞的激活。然而,这种光遗传学存在一定局限性,它只能在数毫米的范围内发挥作用,难以抵达深层组织。
Chimeric antigen receptor T (CAR T) cells are a novel form of immunotherapy in which T cells from patients with cancer are genetically modified to express a chimeric receptor enabling them to target cancer cells, with profound anti-tumour effects. CAR T cells have shown highly impressive results...
[1] Yang, Kailin et al. “Antigen presentation in cancer - mechanisms and clinical implications for immunotherapy.” Nature reviews. Clinical oncology vol. 20,9 (2023): 604-623. [2] Cartellieri, Marc et al. “Chimeric antigen receptor-engineered T cells for immunotherapy of cancer.” Journal...
相关研究结果于2024年8月7日在线发表在Journal for ImmunoTherapy of Cancer期刊上，论文标题为“EphA3 CAR T cells are effective against glioblastoma in preclinical models”。论文共同通讯作者、昆士兰医学研究所的Rajiv Khanna AO教授说，“这种疗法专门针对癌细胞，有潜力防止疾病复发，这对患上这种致命疾病的患者...
[1].Safarzadeh Kozani P, Naseri A, Mirarefin SMJ, Salem F, Nikbakht M, Evazi Bakhshi S, Safarzadeh Kozani P. Nanobody-based CAR-T cells for cancer immunotherapy. Biomark Res. 2022 Apr 25;10(1):24. doi: 10.1186/s40364-022-00371-7. ...
[2] Chan LY, Dass SA, Tye GJ, Imran SAM, Wan Kamarul Zaman WS, Nordin F. CAR-T Cells/-NK Cells in Cancer Immunotherapy and the Potential of MSC to Enhance Its Efficacy: A Review. Biomedicines. 2022;10(4):804. Published 2022 Mar 30. doi:10.3390/biomedicines10040804 [3] Wang Y, ...