[4]https://healthtree.org/myeloma/community/articles/myeloma-story-car-t-therapy [5https://www.clinicaltrialsarena.com/projects/abecma-idecabtagene-vicleucel-multiple-myeloma/?cf-view [6]https://www.globenewswire.com/en/n...
Ide-cel, an autologous B cell maturation antigen (BCMA) targeting CAR-T cells, has recently been approved to treat multiple myeloma (MM). Here, we review the main clinical trials of CAR-T cells in MM with the most advanced autologous BCMA-directed ide-cel and cilta-cel, the human CARs...
1.CAR T-Cells in Multiple Myeloma: State of the Art andFuture Directions.Front Oncol. 2020; 10: 1243. 2.Overview of anti-BCMA CAR-T immunotherapy for multiplemyeloma and relapsed/refractory multiple myeloma. Scand J Immunol. 2020Aug;92(2):e12910. 3.B-Cell Maturation Antigen (BCMA) as ...
截止2018年7月23,clinicaltrials.gov已注册的针对AML的CAR-T临床试验只有12例项目,以CD23和CD123靶点治疗AML研究最多。其中完成的只有1例针对CD123靶点的CAR-T疗法,该项目有患者12例。 1.3 多发性骨髓瘤 多发性骨髓瘤(multiple myeloma,MM)是血液系统中第二大常见恶性肿瘤,源自浆细胞恶变,多发于中老年患者。它主...
总的来说,研究者认为还需要关于安全性和有效性评估、人群和试验设计的统一报告信息。未来在对MM CAR-T细胞治疗的研究中,筛选患者、设计新产品和确定治疗算法等因素,都应纳入考虑范畴。 参考资料: Development of CAR-T cell therapies for multiple myeloma...
The treatment of multiple myeloma has changed dramatically in recent years, with huge strides forward made in the field. Chimeric antigen receptor T-cell therapy targeting the B cell maturation antigen (BCMA) is now widely approved in relapsed refractory
小编也希望随着CAR-T技术的不断发展，未来可以造福更多的患者，给他们带来更长的生存期，更高的生活品质!参考资料 [1]Zhang X,et al.CAR-T cell therapy in multiple myeloma: Current limitations and potential strategies. Front Immunol. 2023 Feb 20;14:1101495. doi: 10.3389/fimmu.2023.1101495.https:/...
Clinical manufacturing of CAR T cells: foundation of a promising therapy. Mol. Ther. Oncolytics 3, 16015 (2016). CAS PubMed PubMed Central Google Scholar Raje, N. et al. Anti-BCMA CAR T-cell therapy bb2121 in relapsed or refractory multiple myeloma. N. Engl. J. Med. 380, 1726–...
总的来说,研究者认为还需要关于安全性和有效性评估、人群和试验设计的统一报告信息。未来在对MM CAR-T细胞治疗的研究中,筛选患者、设计新产品和确定治疗算法等因素,都应纳入考虑范畴。 参考资料: Development of CAR-T cell therapies for multiple myeloma...
治好Emily的CAR-T疗法的原理说来也简单，人体内的T细胞是一种免疫细胞，负责消灭进入人体的外来病原或者肿瘤细胞。T细胞有很多种，其中一种为细胞毒性T细胞(cytotoxic T cell)，它的功能主要是认出异常的细胞，分泌细胞毒素，然后干掉这些不属于机体本身的“坏蛋”。 当我们出现了肿瘤细胞或者被病毒感染的细胞，就需要...