Over the past decade, chimeric antigen receptor (CAR)-T cell therapy has emerged as a revolutionary immunotherapeutic approach to combat cancer. This therapy constructs a CAR on the surface of T cells through genetic engineering techniques. The CAR is fo
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These preliminary results suggest that donor-derived CD7 CAR-T-cell therapy shows encouraging safety and efficacy. In addition to the application of CAR-T-cell therapy alone, researchers have explored the combined strategy of bridging HSCT following CAR-T-cell therapy. Notably, Yongxian Hu and ...
Compressed natural gas is widely concerned as an environmentally friendly alternative for diesel, since it shows low emission, high efficiency and clean combustion [54]. However, little is known about how these two PMs affect human microglia. Understanding the impact of PM specifically on human ...
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Kyverna成立于2018年,是一家专注于开发自免疾病的CAR-T疗法公司。此次获得FDA快速通道认定的KYV-101是一种新型的全人源CD19 CAR-T细胞疗法,其特性尤其适用于治疗B细胞驱动的自身免疫性疾病,如狼疮性肾炎(LN)、系统性硬化症(MS)和炎性肌病。在临床前研究证明,该疗法可在疾病模型的血液循环和组织中深度诱导和完全...
This technology shows promise in enhancing CAR-T cell therapy efficacy by addressing T cell exhaustion and improving anti-cancer capabilities within the tumor microenvironment. Empirical validation in murine models demonstrates MEGA-CRISPR’s ability to enhance tumor cell killing efficiency, leading to ...
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BCMA-directed autologous chimeric antigen receptor T (CAR-T) cells have shown excellent clinical efficacy in relapsed or refractory multiple myeloma (RRMM), however, the current preparation process for autologous CAR-T cells is complicated and costly. Moreover, the upregulation of CD47 expression ha...
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