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然而,由于实体瘤的肿瘤微环境(TME)的免疫抑制作用,CAR-T细胞疗法对实体瘤的疗效有限。目前已上市的CAR-T细胞疗法也都是用于治疗血液系统恶性肿瘤。TME中的抗原刺激和免疫抑制因子导致进入肿瘤内的CAR-T细胞部分失去增殖能力和抗肿瘤活性,这种状态被称为T细胞耗竭(T cell exhaustion),与代谢适应性下降和线粒体功能障碍有...
在DeviceA上配置层次化CAR的父子策略,父策略用来区分不同的部门(VPN1、VPN2、other-VPN),子策略用来区分部门内不同的业务(service1~service3)。 配置子策略,通过应用识别来区分不同的业务(需要在执行策略的接口下开启应用识别功能)。该企业使用WeLink来承载办公应用,语音业务(WeLink_VideoCall)、视频会议业务(WeLink...
The sinusoidal endothelial cell C-type lectin (LSECtin) is present in the liver and lymph nodes. It belongs to the DC-SIGN family molecules and is suggested as a ligand for LAG3. This molecule binds to LAG3′s four glycosylated sites. LSECtin is expressed in melanoma and liver cancer ...
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Chimeric antigen receptor (CAR) T-cell therapy that targets B-cell maturation antigen (BCMA) have great potentials in autoimmune diseases and could be novel therapeutics for relapsed/refractory neuromyelitis optica spectrum disorder (NMOSD). To evaluate the safety and efficacy of the CT103A, a sel...