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thereby improving CAR-T cell persistence [118]. Beyond modifying CAR co-stimulatory signals, engineering appropriate cytokines is also a strategy to enhance CAR-T cell persistence. Research suggested that modifying CAR T cells to secrete IL-7 enhanced CAR-T...
Parker, P. Xu, A. Fan, E. Sotillo, M. Daugaard, H.Z. Oo, J. Liu, et al. NOT-Gated CD93 CAR T Cells Effectively Target AML with Minimized Endothelial Cross-Reactivity Blood Cancer Discov., 2 (2021), pp. 648-665 CrossrefGoogle Scholar 68 M. Hamieh, J. Mansilla-Soto, I. ...
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(AAV) vector repair matrix to insert a CD19-specific CAR construct into the TRAC locus. CAR-T cells generated by CRISPR knock-in strategy outperformed the CAR-T cells generated via retroviral infection, both in vitro and in vivo [203]. These studies also demonstrated that targeting the CAR ...
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作者: V Parker 摘要: Back in the 1980s, when Richard Fortin was a printer in Washington, he restored a 1937 Oldsmobile coupe. It turned out beautifully in every way with one exception - the old car couldn't keep up with modern-day traffic....
Overall, this is a really sharp car that you would swear is a reproduction and not a survivor. Can you imagine the stories this car could tell from the 50s and 60s in the Los Angeles area?
This particular stunt is used succssfully by the protagonist robber in one of the Parker novels by Richard Stark (i.e. Donald Westlake). The Porsche is the 2.0-litre engined 911 (1964-1969) and the engine can provide in stock form from 110-130 hp in milder versions to 180-190 hp in...