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CARs are fusion proteins typically combining extracellular monoclonal antibody-derived targeting fragments with intracellular signaling domains that activate T cells (Fig.1A). Variable light (VL) and heavy (VH) chains are linked by a flexible peptide to form a single chain variable fragment (scFv) t...
115,116]. Despite depleting TCR+cells from the product, GVHD was seen in conjunction with expansion of CAR+TCR+T cells in 10% patients. While the results in B-ALL are inferior to those seen with autologous products, they provide a reference point for future products...
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