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Tumour tropism represents an important aspect in engineering these viruses and it can be either a native feature of the virus or gained through the insertion of specific genes, expressing ligands that can bind to receptors ubiquitously present in cancers such as adenovirus type 3 (Ad3) or herpes...
PD-1 on activated T cells with its ligands PD-L1 (B7-H1 or CD274) and PD-L2 (B7-DC or CD273) maintains immunologic tolerance through the suppression of auto-reactive T cells [2]. Likewise, in the tumor microenvironment, the interaction of the PD-1 on tumor infiltrating T cells (TILs...
The porosity of the tucum fiber was also investigated through the methods indicated by Luz et al. [32] and Mwaikambo and Ansell [33]. The tucum fiber surface morphology was characterized by scanning electron microscopy (SEM) in a model Quanta FEG 250 Fei microscope (Hillsboro, OR, USA) ...
Sorting through subsets: Which T-cell populations mediate highly effective adoptive immunotherapy? J. Immunother. 2012, 35, 651–660. [CrossRef] [PubMed] 33. Turtle, C.J.; Berger, C.; Sommermeyer, D.; Hanafi, L.A.; Pender, B.; Robinson, E.M.; Melville, K.; Budiarto, T.M.; ...