Chinese President Xi Jinping said Monday that implementation of the Belt and Road Initiative is in full swing. 14 climbers set foot on Mt. Qomolangma as first team of 2017 from Nepal side A team of 14 rope-fixing climbers on Monday stood atop the world's highest peak Mount Qomolangma, beco...
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Full size image PD1 is highly expressed in exhausted CD8 + T cells, and targeting PD1 could enhance CD8 + effector T-cell function and inhibit the malignant progression of tumors [41, 42]. Here, we found that among these four common markers of CD8 + T cell exhaustion, PD1...
low pH, and accumulated immunosuppressive metabolites [122]. The energy requirements of CAR-T cells to maintain effective responses in TIME cannot be met, thus affecting the tumor-control effect [122,123]. Metabolomics could describe the full physiological state of cells at a...
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