After wide use of captopril, enalapril and lisinopril, and investigational trials of nearly a dozen newer agents, a sufficiency of clinical observation, ... RC Parish,LJ Miller - 《Drug Saf》 被引量: 153发表: 1992年 Rational experimental design for bioanalytical methods validation. Illustration us...
Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be...
Two-way ANOVA followed by Bonferroni post hoc analysis for (A) to (J). Full size image As shown in Fig. S6, mesenteric arteries dissected from Ang II-induced hypertensive CTR mice were preincubated for 6 h separately with vehicle, captopril, lisinopril (ACEI that does not stimulate B1R...
Both the renal and hindquarter vascular responses to AA were abolished by 5 mg of indomethacin/kg i.v. A dose of captopril (0.5 mg/kg) shown effective in blocking conversion of angiotensin I to angiotensin II did not affect the ... HM Sakr,EW Dunham - 《Journal of Pharmacology & Experim...