Previous work on the assembly of brome mosaic virus (BMV, closely related to CCMV) on spherocylindrical substrates reported a dependency between the diameter of the rod and the preferred location of nucleation along the rod13,35. For 6HB-500, although the length/progression of the coating is...
Virus - Structure, Capsid, Genome: The amount and arrangement of the proteins and nucleic acid of viruses determine their size and shape. The nucleic acid and proteins of each class of viruses assemble themselves into a structure called a nucleoprotein,
The reductionist system of Nup98 condensates allows us to demonstrate the principle of FG-mediated phase partitioning and probe the specific sites on the capsid that permit it to be a client of these phases. We acknowledge that the human NPC is one of the most complex macromolecular assemblies ...
in virus assembly, binding viral glycoproteins through its glycoprotein-binding hydrophobic pocket. We showed that non-aromatic cyclic compounds like dioxane disrupt this vital interaction. Our findings provide deeper insights into ONNV's biology, and we believe they will prove instrumental in guiding t...
Virus Capsid Viral capsids are the protein cage derived from the protein shell of a virus, and can have different shapes, sizes, and protein subunits, depending on the virus type [101]. The interior, interface, and exterior features are made up of amino acid residues, which afford numerous...
D.A. Padgett, ... J.F. Sheridan Explore book Glossary Capsid The protein coat or shell that contains the nucleic acid genome of the virus particle. The individual morphological units (or sides) on the surface of the capsid. Envelope The lipid-containing outer membrane that surrounds the enti...
on capsid disassembly, a highly coordinated process that needs to be executed in a temporally and spatially controlled manner for optimal infectivity [7,8]. The HIV-1 capsid directly interacts with multiple host factors that can either promote or thwart virus infection [9]. The complex interplay...
Transformation of a Viral Capsid from Nanocages to Nanotubes and Then to Hydrogels: Redirected Self-Assembly and Effects on Immunogenicitydoi:10.1021/acsnano.4c01969self-assemblyvirus-like particlesnanotubeshydrogelseffectsnanovaccinesThe ability to manipulate the self-assembly of proteins is essential to ...
Sangamo will receive a $20 million upfront license fee from Astellas and is eligible to earn up to $1.3 billion in additional licensed target fees and milestone payments across the five potential neurology disease targets, as well as tiered mi...
Long-acting ARVs promise to build on the success of current PrEP strategies, which must be taken daily, by reducing the frequency of administration3. GS-CA1 is a small-molecule HIV capsid inhibitor with picomolar antiviral potency against a broad array of HIV strains, including variants ...