CAPPED AND UNCAPPED RNA MOLECULES AND BLOCK COPOLYMERS FOR INTRACELLULAR DELIVERY OF RNAThe present invention relates to the use of at least one tetra functional non-ionic amphiphilic block copolymer as a vehicle for capped or uncapped mRNA for intracellular delivery for gene therapy.PITARD Bruno...
公开/公告号: WO 2015151048 A1 申请(专利权)人: 发明人: B Pitard 国省代号: WO 摘要: The present invention relates to the use of at least one tetra functional non-ionic amphiphilic block copolymer as a vehicle for capped or uncapped mRNA for intracellular delivery for gene therapy.收藏...
canonical m7G cap 5′-end. Whether an mRNA is uncapped or capped but missing the N7 methyl moiety, Rai1 hydrolyzes its 5′-end to generate an mRNA with a 5′ monophosphate. Interestingly, Rai1 heterodimerizes with the Rat1 5′–3′exoribonuclease, which subsequently degrades the 5′-end...
5′-cap or 5′-hydroxyl group had no or little effect on the amount ofJPT2andCDKN1Btranscripts detected with primers amplifying either side of the 3′UTR CAGE peak within these cells. This was in sharp contrast with the known uncapped 3′ fragment ofSLC38A2mRNA, previously described by Mal...
Translation of capped and uncapped VSV mRNAs in the presence of initiation factors from poliovirus-infected cells Each was compared with capped and methylated VSV mRNA and with poliovirus RNA for its recognition by initiation factors from uninfected or poliovirus-infected HeLa cells. The results show...
United States Patent US11179478 Note: If you have problems viewing the PDF, please make sure you have the latest version of Adobe Acrobat. Back to full textHome Search Services Contact us © 2004-2024 FreePatentsOnline.com. All rights reserved. Privacy Policy & Terms of Use....
CAPPED AND UNCAPPED RNA MOLECULES AND BLOCK COPOLYMERS FOR INTRACELLULAR DELIVERY OF RNAThe present invention relates to the use of at least one tetra functional non-ionic amphiphilic block copolymer as a vehicle for capped or uncapped mRNA for intracellular delivery for gene therapy.Bruno Pitard...
CAPPED AND UNCAPPED RNA MOLECULES AND BLOCK COPOLYMERS FOR INTRACELLULAR DELIVERY OF RNAThe present invention relates to the use of at least one tetra functional non-ionic amphiphilic block copolymer as a vehicle for capped or uncapped mRNA for intracellular delivery for gene therapy.PITARD, Bruno...
CAPPED AND UNCAPPED RNA MOLECULES AND BLOCK COPOLYMERS FOR INTRACELLULAR DELIVERY OF RNAThe present invention relates to the use of at least one tetrafunctional non-ionic amphiphilic block copolymer as a vehicle for capped or uncapped mRNA for intracellular delivery for gene therapy.BRUNO PITARD...
CAPPED AND UNCAPPED RNA MOLECULES AND BLOCK COPOLYMERS FOR INTRACELLULAR DELIVERY OF RNAThe present invention relates to the use of at least one tetra functional non-ionic amphiphilic block copolymer as a vehicle for capped or uncapped mRNA for intracellular delivery for gene therapy.BRUNO PITARD...