(i) Natural cannabinoids are obtained from the inflorescence of Erythroxylum coca (ii) Marijuana, Hashish, Charas and Ganja are obtained from flower tops, leaves and the resin of Papaver somniferum (iii) Cannabinoids are generally taken by inhalation and oral ingestion (iv) Cannabinoids have ...
Synthetic cannabinoids are obtained to mimic the effects of marijuana, are major cannabinoid receptor agonists and are at increased risk of toxicity. Chronic consumption of such substances can cause memory disorders, pulmonary disorders and, most importantly, addiction.Lupu, Mary NicoletaMiulescu, ...
The respective mussel species were obtained from three different sites in both New Zealand (NZ) and Tasmania. Lipid class distribution of both mussel species was characterized by a high proportion...DOI: 10.1016/S1526-5900(00)90084-1 被引量: 11 ...
Phytocannabinoids, including Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), are found in the cannabis plant [81]. THC is a partial agonist of the cannabinoid receptors with high affinity at CB1 and CB2 receptors [62], binding the same site as AEA and 2-AG. Instead, CBD mostly target...
Indeed, Δ8-THC (14) and its pharmaceutically relevant derivative 15 could be obtained from the reaction of isopiperitenol (2) and either olivetol (12a) or 5-(1,1-dimethylheptyl)resorcinol (12c) at ambient temperature, by employing 20 mol% trimethylsilyl triflate as the catalyst. To ...
All other cannabinoids were obtained at ≥ 98% purity from Aurora Prairie (Aurora Cannabis Inc., Saskatoon, SK). Because concern exists regarding the stability plant-derived cannabinoids, such as ∆9-THCa undergoing spontaneous decarboxylation, all compounds were aliquoted, stored at − 80...
are therapeutically relevant. CBD parks at a different docking site on the CB1-R that is functionally distinct from THC’s orthosteric binding site. CBD attaches to what’s known as an “allosteric” binding site on CB1-R. When CBD docks at the receptor, it does not initiate a signaling ...
Clinical Evidence of Sex-Dependent Effects Survey/self-report data obtained from medical cannabis dispensaries. Although rates of cannabis use are consistently higher among men, data from surveys of medical cannabis users demonstrate that the gender gap is narrowing. In 2007– 2008, close to 40% ...
Survey/self-report data obtained from medical cannabis dispensaries Although rates of cannabis use are consistently higher among men, data from surveys of medical cannabis users demonstrate that the gender gap is narrowing. In 2007–2008, close to 40% of chronic pain patients who sought legal quali...
(Devon, PA, USA). Other CBD-containing products are available commercially and obtained online [e.g., Realm of Caring's Charlotte's Web (whole cannabis extract containing 50 mg/ml CBD)]. However, the quality control and consistency of these products may vary considerably. Indeed, a recent ...