Now it’s time to compare the heavyweights. CBD and THC are the most well-known cannabinoids, with THC, or tetrahydrocannabinol, perhaps most well known for its role in inducing the “high” typically associated with cannabis consumption. While CBD and THC are the most popular cannabinoids, the...
Male–female differences in the effects of cannabinoids on sexual behavior and gonadal hormone functionSexual behaviorProceptivityReceptivityCannabisCannabinoidEndocannabinoidTHCTestosteroneGonadotropinThe putative role of the endocannabinoid system and the effects of cannabis use in male and female sexual ...
36 treated female and male rats also produced greater anti- allodynic and anti-hyperalgesic effects in females, suggesting that sex differences in peripheral cannabinoid function contribute to sex differences in cannabinoid antinociception. Given the consistently greater antinociceptive effect of THC in ...
Side effects associated with THC are different than CBD. In general, dizziness and fatigue are the most common adverse events people using THC or a combination of THC and CBD experience.3 THC use may negatively affect memory and lead to decreased ability to engage in activities that require han...
Nabiximols, also known as Sativex®, is a Food and Drug Administration (FDA)- approved oromucosal spray containing CBD and THC extracts in a 1:1 ratio derived from the cannabis plant that is approved for treatment of spasticity associated with multiple sclerosis. Epidiolex® is pharmaceutical...
The discovery of the anticarcinogenic effect of cannabinoid compounds can be dated back to Munson et al. [26], who were able to show in the mid-1970s that THC, Δ8-THC and cannabinol inhibit Lewis lung adenocarcinoma growth in mice. However, the discovery of cannabinoid receptors years late...
t decarboxylate into CBG, CBGA can also transform into THCA or CBDA, the carboxylic acid precursors of THC and CBD respectively. As a result, cannabis scientists have taken to calling CBGA the “stem cell” cannabinoid, and this unique hemp constituent becomes even more fascinating once it ...
Cannabis and cancer chemotherapy: a comparison of oral delta-9-THC and prochlorperazine. Cancer. 1982;50(4):636-645.PubMedGoogle ScholarCrossref 47. Sheidler VR, Ettinger DS, Diasio RB, Enterline JP, Brown MD. Double-blind multiple-dose crossover study of the antiemetic effect of ...
The marked variations in the THC-COOH concentrations between body regions may be explained by differences in the physiology (e.g. presence of apocrine sweat glands in the axillary and pubic region), sampling particularities (e.g. regular shaving of beard hair vs. sampling of hair strands) and...
An interesting formulation to be investigated at the clinical level is the recently licensed phytocannabinoid-based medicine Sativex (GWPharma), which, based on the activity of its 2 components, Δ9-THC and CBD, at different complementary targets identified as neuroprotective in AD, e.g. CB1R ...