A9-THC, the main psychoactive cannabinoid from the Cannabis plant, binds to specific binding sites in humans, which are situated in membranes of nerve and several other cells in both the central nervous system and peripheral organs. Evidence for the existence of the specific action of cannabinoids...
An Endogenous Cannabinoid System (ECS), commonly referred to as an “Endocannabinoid System,” is found in every animal and regulates a broad range of biological functions. The ECS is a biochemical control system of neuromodulatory lipids (molecules that include fats, waxes, sterols and fat-solubl...
Immune systemImmunosuppressionDer Einsatz von Cannabinoiden oder Cannabis in der Medizin wird kontrovers diskutiert. Derzeit sind nur Einzelsubstanzen (Dronabinol, Nabilone ) zur Symptomkontrolle in der Palliativmedizin zugelassen.Das physiologische Cannabinoidsystem mit den spezifischen Rezeptoren CB 1 ...
(redirected fromEndogenous cannabinoid system) A family of short-lived phospholipid-derived agonists that activate receptors in the brain, liver, muscle, intestine and adipose tissue. The system has roles in regulating energy balance and obesity. ...
The complex neurological network responsible for producing, processing and utilizing these cannabinoids is known as the endogenous cannabinoid system, and it was discovered by the same person who first synthesized THC — Dr. Mecholuam. There are many distinct physiological processes regulated or affected...
Later, the discovery of specific receptors and their endogenous ligands (endocannabinoids) suggested the existence of an endogenous cannabinoid system, providing a physiological basis for biological effects induced by marijuana and other cannabinoids. Epidemiological reports describing the appetite-stimulating ...
The analgesic properties of exogenous cannabinoids have been recognized for many years and suggest a regulatory role for the endogenous cannabinoid (“endocannabinoid”) system in mammalian nociceptive pathways. The endocannabinoid system includes: (1) at least two families of lipid signaling molecules, ...
In recent decades, the endocannabinoid system has attracted considerable attention as a potential therapeutic target in numerous physiological conditions, such as in energy balance, appetite stimulation, blood pressure, pain modulation, embryogenesis, nausea and vomiting control, memory, learning and immune...
cannabinoid system in cellular survival, involving the CB1 receptor, which occurs by positive regulation of the anti-apoptotic proteins, suggesting the participation of this system in neurodegenerative processes. Our data suggest that the cannabinoid system is an interesting therapeutic target for the ...
The endogenous cannabinoid system (ECS) regulates cytokine production and mitigates pathophysiology in many pro-inflammatory conditions, such as irritable bowel diseases, atherosclerosis and acute lung injury. Sepsis, a highly morbid condition, results from a dysregulated host response to infection. Despite...