Several mast cell tumor therapeutic approaches have been proposed in the past years for dogs and cats, resulting in very distinct outcomes. The current comprehensive literature review presents a critical approach to the scientific information published about the MCTs treatments and the subsequent ...
Sue Ettinger, DVM, DACVIM (Oncology): There’s so many almost controversies with mast cell tumors and really figuring out what the right treatment option [is], but when I think about [mast cell tumors] I just want pet owners and veterinarians to remember the majority of them are treatable...
For 58 cases of canine mast cell tumors, we measured the tumor volume reduction following one to four weeks of treatment with prednisolone administered once per day. The median dose of prednisolone was 21.5 mg/m2. We observed tumor reduction in 35 cases, with a response rate of 60.4%. In...
Multi-center, placebo-controlled, double-blind, randomized study of oral toceranib phosphate (SU11654), a receptor tyrosine kinase inhibitor, for the treatment of dogs with recurrent (either local or distant) mast cell tumor following surgical excision Clin Cancer Res, 15 (11) (2009), pp. 385...
Bergman PJ, Couto GC, Mauldin GN, Michels GM: Multi-center, placebo-controlled, double-blind, randomized study of oral toceranib phosphate (SU11654), a receptor tyrosine kinase inhibitor, for the treatment of dogs with recurrent (either local or distant) mast cell tumor following surgical excisi...
Mast cell tumour (MCT) is a life-threatening neoplasm commonly found in dogs worldwide. The outcome of treatment for dogs with cutaneous MCT is currently poor, mainly because of the tumour’s aggressiveness and the heterogeneity in tumour behaviour. This study established a novel canine MCT cell...
Masitinib is Safe and Effective for the Treatment of Canine Mast Cell Tumors Background: Activation of the KIT receptor tyrosine kinase is associated with the development of canine mast cell tumors (MCT). KA Hahn,G Oglivie,T Rusk,... - 《Journal of Veterinary Internal Medicine》 被引量: ...
A Case of Poorly Differentiated Cutaneous Canine Mast Cell Tumor with an Atypical Dermatologic PresentationVichi GBinanti DCiaccini RCostantini L
Next, we assessed the correlation between reovirus replication and anti-tumor effects in canine melanoma cell lines. Western blotting detected reovirus proteins in reovirus-infected CMeC1 and KMeC cells and further revealed that combination treatment (i.e., reovirus infection in the presence of KU600...
This study provides a unique translational research opportunity to help both humans and dogs diagnosed with diseases that carry dismal prognoses in both species: histiocytic sarcoma (HS), hemangiosarcoma (HSA), and disseminated mastocytosis/mast cell tumor (MCT). Although exceedingly rare in humans,...