Keywords: mitotic index, mastocytosis, tyrosine kinase inhibitor, histologic gradedoi:10.2147/VMRR.S41005Garrett LauraDove PressVeterinary Medicine Research & ReportsGarrett LD. Canine mast cell tumors: diagnosi
think about [mast cell tumors] I just want pet owners and veterinarians to remember the majority of them are treatable and even for those subset of high grade mast cell tumors, a lot of the recent studies show if we treat them aggressively they can actually have a really good prognosis. ...
Differences in the frequency of somatic mutations imply their direct association with the neoplastic transformation. However, their functional consequences and clinical significance are not clear. The mutations may be used for diagnosis and prognosis of canine mast cell tumours in the future. Findings M...
Multi-center, placebo-controlled, double-blind, randomized study of oral toceranib phosphate (SU11654), a receptor tyrosine kinase inhibitor, for the treatment of dogs with recurrent (either local or distant) mast cell tumor following surgical excision Clin Cancer Res, 15 (11) (2009), pp. 385...
These results indicate that all mutations observed arose soma- tically in each tumor. Interestingly, these deletion mutations are similar to those previously found in the juxtamembrane domain of c-KIT in canine cutaneous mast cell tumors in our laboratory [34] and others [13]. In a previous ...
CSF-1 and CCL2 are known mod- ulators of the fate of macrophages, both driving the production of M2 cells and being correlated to poor prognosis in cancer [5, 28]. Our understanding of the interaction between TAMs and cancer cells is still evolving [6], as is the very classifica- ...
L. 1996 Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Research, 56 20 (October 15 1996), 4625 4629 , 0008-5472 41. Mantovani A. Sozzani S. Locati M. Allavena ...
P-glycoprotein expression showed to be related with regional lymph node spread (P = 0.0038), as well as with tumor grade (P = 0.0353) and with a shorter survival (P = 0.0245). MRP1 revealed a strong association with a higher histological grade (P < 0.0001) and overall survival (P = ...
B cell lymphomas have been found to have a better prognosis than most T cell lymphomas [5]; however, specific immunotypes in T cell lymphoma are associated with improved survival and a longer progres- sion free interval [6]. A number of studies have explored methods to predict outcome in ...
The subcutaneous variant of canine mast cell tumour is distinct in having features of intermediate histological grade and extended mean survival times, suggesting a slightly better long-term prognosis than for higher grade dermal variants. Expression of nuclear proliferation markers is not associated with...