Laura D Garrett Department of Veterinary Clinical Medicine, University of Illinois College of Veterinary Medicine, Urbana, IL, USA Abstract: Mast cell tumors (MCTs) are the most common malignant skin cancer in dogs, and significant variability exists in their biological behavior. Most MCTs are ...
think about [mast cell tumors] I just want pet owners and veterinarians to remember the majority of them are treatable and even for those subset of high grade mast cell tumors, a lot of the recent studies show if we treat them aggressively they can actually have a really good prognosis. ...
Cutaneous-origin MCT demonstrated increased apoptosis compared to the mucosal counterparts, consistent with their poorer prognosis [3, 4]. Co-culturing significantly enhanced early and total apoptosis across all cell lines, supporting reports of PBMC-induced apoptosis in cancer cells [53, 54]. The ...
CSF-1 and CCL2 are known mod- ulators of the fate of macrophages, both driving the production of M2 cells and being correlated to poor prognosis in cancer [5, 28]. Our understanding of the interaction between TAMs and cancer cells is still evolving [6], as is the very classifica- ...
Mast cells (MCs) are well known for their neoplastic transformation in solitary and multiple cutaneous mast cell tumours (MCTs), as well as visceral and sy... MM Welle,CR Bley,J Howard,... - 《Veterinary Dermatology》 被引量: 237发表: 2008年 Prognosis of Canine Mast Cell Tumors: A Comp...
Differences in the frequency of somatic mutations imply their direct association with the neoplastic transformation. However, their functional consequences and clinical significance are not clear. The mutations may be used for diagnosis and prognosis of canine mast cell tumours in the future. ...
Furthermore, there has been increasing evidence that COX-2 overexpression is associated with tumourigenesis [4], angiogenesis [5], resistance to apoptosis, cancer cell proliferation and metastasis [6],[7]. COX-2 protein expression has been associated with a poor prognosis in human breast cancer ...
Human inflammatory breast cancer (IBC) and canine inflammatory mammary cancer (IMC) are comparable diseases [5,10,11]. IBC/IMC is a very aggressive type of breast cancer with poor prognosis [1,2,3,4,5]. IBC/IMC has specific carcinogenic mechanisms, including high rates of metastasis and in...
Newman SJ, Mrkonjich L, Walker KK, Rohrbach BW: Canine subcutaneous mast cell tumour: diagnosis and prognosis. J Comp Pathol. 2007, 136 (4): 231-239. 10.1016/j.jcpa.2007.02.003. Article CAS PubMed Google Scholar Higgins RJ, Dickinson PJ, LeCouteur RA, Bollen AW, Wang H, Corely LJ...
Overexpression of the cancer stem cell marker CD117 predicts poor prognosis in epithelial ovarian cancer patients: evidence from meta-analysis OncoTargets Ther, 10 (2017), pp. 2951-2961 View in ScopusGoogle Scholar [41] L. Cao, M. Shao, J. Schilder, T. Guise, K.S. Mohammad, D. Matei...