Fig. 4: Absence of TYK2 or its kinase activity alters the transcriptome of skin-infiltrating myeloid cells. aWT,Tyk2-/-andTyk2K923Emice were infected as described in the legend to Fig.1. RNA from skin-sorted CD45+CD3-CD19-NK1.1-myeloid cells was isolated for subsequent RNA-sequencing.bVo...
Gangneux, Jean-PierreLaboratory of Mycology, Centre Hospitalier Universitaire de Rennes, Centre National de référence pour les mycoses et antifongiques – LA AspC, ECMM Excellence Center for Medical Mycology, Rennes, FranceMaertens, JohanDepartment of Haematology and ECMM Excellence Center for Medical...
Our previous studies have shown that the opportunistic pathogenic fungal pathogen, Candida tropicalis (C. tropicalis) promotes CRC progression by enhancing the immunosuppressive function of MDSCs and activating the NLRP3 inflammasome of MDSCs. However, the relationship between IL-1β produced by NLRP3...
doi:10.1038/s41467-024-44825-yFan, XinDai, Rong-ChenZhang, ShuGeng, Yuan-YuanKang, MeiGuo, Da-WenMei, Ya-NingPan, Yu-HongSun, Zi-YongXu, Ying-ChunNature Publishing Group UKNature Communications
Abdullah Osme 2, Carlo De Salvo 3, Eleonora Zoli 4,5, Janet Herrada 1, Thomas S. McCormick 1, Mahmoud Ghannoum 1, Fabio Cominelli 3,4,5and Luca Di Martino 4,5,*,† 1 Center for Medical Mycology and Integrated Microbiome Core, Department of Dermatology, University Hospitals Cleveland...