The COSMIC database (version 94) lists 576 genes in the Cancer Gene Census which have a defined function as drivers of malignancy (oncogenes) or as tumour suppressors (Tier 1). In addition, there are 147 genes with sirnilar functions, but which are less well characterised (Tier 2). ...
The emergence of large-scale multi-omics data warrants method development for data integration. Genomic studies from cancer patients have identified epigenetic and genetic regulators – such as methylation marks, somatic mutations, and somatic copy numbe
Based on the lung adenocarcinoma(LUAD)gene expression data from the cancer genome atlas(TCGA)database,the Stromal score,Immune score and Estimate score in ... Z Ye,P Song,D Zheng,... - 传染病建模(英文) 被引量: 0发表: 2022年 Candidate Genes Identified by Constructing a Weighted Gene Co...
STAT3 is a central hub associated with GBM progression and one of the master regulators of mesenchymal transformation [26]. In this study, we found that GBM cells overexpressing RPL22L1 activate the STAT3 pathway, making these cells dependent on the STAT3 pathway. As an apoptosis-inhibiting gene...
The website is searchable by gene, chromosome, gene ontology pathway, dbSNP ID and SNP500Cancer SNP ID. As of October 2005, the database contains >13400 SNPs, 9124 of which have been sequenced in the SNP500Cancer population. For each analysed SNP, gene location and >200 bp of surrounding...
As a first step, we have compiled from the literature an initial set of differentially expressed human candidate cancer biomarkers. Each candidate is annotated with information from publicly available databases such as Gene Ontology, Swiss-Prot database, National Center for Biotechnology Information's ...
Nasopharyngeal carcinoma (NPC) is a common cancer found in the nasopharynx with high metastatic and invasive nature. Increasing evidences have identified the critical role of gene therapy in NPC treatment. Hence, this study was designed ... K Xue,J Cao,Y Wang,... - 《Clinical & Translational...
The other gene (grail.54.31.1) in Ciona contains a CARD and a putative NB domain both of that commonly found in the CED-4/Apaf-1-related proteins. However, the phylogenetic analysis shows that there are no significant similarities between grail.54.31.1 and CED-4/Apaf-1 genes (data not ...
GT41 is a multispecific family in the CAZy database, with N-glucosyltransferase, N-acetylglucosaminyl-transferase and protein O-fucosyltransferase activity, the latter being restricted, so far, to the green lineage [47]. Brown algal genomes harbor ten GT41 genes on average, with homologues found...
To determine the extent of cdc2 expression across human tissues we utilized the ASCENTA System, an integrated human biological database developed at Gene Logic Inc. Data from over 800 tissue sample sets comprising more than 6400 unique biological samples were analyzed using the HG-U133 GeneChip. ...