Sex-associated differences in bone metastasis formation from breast, lung, and prostate cancer exist in clinical studies, but have not been systematically reviewed. Differences in the bone marrow niche can be attributed to sexual dimorphism, to genetic variations that affect sex hormone levels, or to...
radiation therapy, advanced tumors that have spread to the bone and cranial nerves are difficult to control. Surgery is not very helpful and, hence, is rarely attempted. Radiation remains the only treatment of choice to treat the cancer that has metastasized (traveled) to the lymph nodes in ...
Haematological malignancies are a diverse group of cancers that affect the blood, bone marrow and lymphatic systems. Laboratory diagnosis of haematological malignancies is dependent on combining several technologies, including morphology, immunophenotyping, cytogenetics and molecular genetics correlated clinical ...
The National Cancer Institute and the National Human Genome Research Institute have partnered to create The Cancer Genome Atlas project (http://cancergenome.nih.gov/), which expects to create a library of genetic information on more than 20 cancers that affect adults. The project will use its ...
et al. ATM germline pathogenic variants affect outcomes in children with ataxia-telangiectasia and hematological malignancies. Blood https://doi.org/10.1182/blood.2024024283 (2024). Winter, G. et al. Clinical and genetic characteristics of children with acute lymphoblastic leukemia and Li–Fraumeni ...
Haematological malignancies are a diverse group of cancers that affect the blood, bone marrow and lymphatic systems. Laboratory diagnosis of haematological... John A SnowdenSusan O'ConnellJames HawkinsChris DalleyAndrew JackDeepak MannariChris McNamaraMike ScottGeoff ShentonElizabeth SoilleuxFergus Macbeth...
Besides, distinct mutational profiles across adenocarcinoma subtypes47,48, as well as intergenic correlations between hotspot mutations17,25 that may affect diagnostic efficiency, also necessitate larger sequencing studies and wider clinical application for further improvements. Today’s clinicians are ...
As radiation treatment was not randomised, selection bias could have resulted in differences between treatment groups with regard to other factors that affect second cancer risk – for example, smoking status, the clinical and pathological features of the initial cancer or concomitant disease. It ...
Hematopoietic cancers (HCs) are a heterogeneous group of malignancies that affect blood, bone marrow and lymphatic system. Here, by analyzing 1960 RNA-Seq samples from three independent datasets, we explored the co-expression landscape in HCs, by inferri
Sarcomas are a group of more than 60 different tumor types that affect bone, muscle, fat,blood vesselsand other tissues. Each of these distinct cancers is individually quite rare, however together they affect about 10,000 people in Europe each year. ...