Agent Orange tied to 3 cancers, 2 skin ailments Study leads US to expand list of illnesses covered by compensationDolores Kong, Globe Staff
Because of concerns among veterans over Agent Orange exposure, the Department of Veterans Affairs (VA) has conducted a series of studies of specific cancer... CM Mahan,TA Bullman,HK Kang,... - 《Journal of Occupational & Environmental Medicine》 被引量: 20发表: 1997年 加载更多来源...
A number of novel anticancer drugs have been developed in recent years. However, the mortality of cancer patients remains high because of the emergence of drug resistance. It was reported that drug resistance might involved in changes in gene expression
The two missense mutations found in the ER gliomas (orange squares), M1839K and I2050N, are in key functional domains of the proteins, SNF2_N and Helicase (He), respectively. SNF2_N domain, amino acid positions 1,536–1,889; helicase domain, amino acid positions 2,018–2,155. ...
Certain gene sequences are chosen by the microRNAs, specifically those associated with the cell cycle (CDK4, CDK6, and CCND1) and those meant to stop cells from dying (BCL2, SIRT1). This selection is intentional and is to serve the functions of the microRNAs. That’s why they’re so...
They propose an unknown infectious agent (mostly viral by Kinlen) that trigger an aberrant immune response and thus can be a causative agent of childhood ALL. A more recent unifying hypothesis, of “cell transformation by replication-defective mutants,” suggests that only viruses which have ...
One such polyphenol is curcumin, which is a hydrophobic orange-yellow crystalline phytochemical isolated from various sources including Curcuma longa [3]. Curcumin is safe, as it is well tolerated even at a dose of 12 g day−1 in phase-I clinical trials and has also been declared as GRAS...
when the targeted micelle active agent carrier is internalized in a cell, for example via an endosomal pathway, and the local pH drops. The reduce pH of some tumors, including the interstitial space, can also be used as a mechanism for triggering or assisting release from the micellar structur...
aProstate cancer cells with wild type (diploid)CHD1(upper left) vs. prostate cancer cells harboring mono-allelic deletion forCHD1(upper right) are visualized by FISH assay. Orange signal:CHD1probe; green signal: human chromosome 5 short arm probe; blue color: DAPI nuclear stain. Arrows are ...
[33]. Accordingly, Cancer therapy may benefit greatly from the study of microRNAs. It’s well-known that miRNAs are known to affect prognosis, diagnosis, therapy, and medication resistance of GI cancer [34,35,36,37,38,39]. We outlined the most recent research on miR-34a functions in GI...