In three mouse models of breast cancer, we show reduced responses to neoadjuvant chemotherapy when treatment is initiated during the dioestrus stage, when compared with initiation during the oestrus stage. Laura Bornes , Lennart J. van Winden & Jacco van Rheenen News & Views | 04 December 2024...
In the final report of a phase 1 trial evaluating intracerebroventricular B7-H3-targeting CAR T cells in children and young adults with diffuse intrinsic pontine glioma, repeated intracranial infusions were feasible and well tolerated with a median overall survival of 19.8 months and 3 patients...
(6 infusions) as a positive control. The other groups were injected with the same volume of PBS. On the 21st day, all animals were euthanized by intraperitoneal injection of 100 mg/kg pentobarbital sodium to collect blood, spleens, and tumors. Throughout the study, the weight changes of ...
Immune microenvironment and immunotherapy have become the focus and frontier of tumor research, and the immune checkpoint inhibitors has provided novel strategies for tumor treatment. Malignant pleural effusion (MPE) is a common end-stage manifestation of lung cancer, malignant pleural mesothelioma and ot...
3. When Johnny was down with cancer, the family’s first priority was to seek medical help. Johnny was sent to a well-known hospital in Kuala Lumpur for treatment. We respected that decision.Go ahead and see what the doctor can offer you!
Immunotherapies, specifically immune checkpoint inhibitors (ICIs) such as programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand 1(PD-L1), provided a significant advance in cancer treatment [1]. CAR-T cell therapy is a novel form of immunotherapy that employs genetic engineer...
Patients with cancer currently undergo lengthy infusions and spend precious time away from friends and family. Teon’s goal is to develop once-daily, oral medications to treat more patients and provide better outcomes allowing patients to spend time on what matters most. Learn More Driven by Sci...
aIn the case of the 67-year old pensioner with prostate cancer, associated with severe lumbar pain, metastases were excluded with great certainty. Orthopedic treatment in the form of injections, infusions and medication was rather unsuccessful. Periradicular therapy carried out by a radiologist under...
Initially, treatment of breast cancer cells with these flavonoids led to an increase in the production of EGFP-LC3 puncta and the accumulation of LC3B-II [106]. Secondly, treatment with these flavonoids reduced the levels of p62, a protein that functions as a cargo receptor for the autophagic...
There are many studies on colitis and colon cancer in dark tea, and more research on the prevention and treatment of cancer in other parts of the body should be carried out in the future. At the same time, most of the studies focus on the apparent but fail to deeply explore the ...