In cancer treatment, toxicity refers to the ill effects of a treatment on healthy cells. Chemotherapy drugs, for example, may work well against cancer but also damage healthy cells. Financial toxicity works the same way. You may be diagnosed with cancer while in a financially healthy position—...
& Li, D. MRE11–RAD50–NBS1 complex alterations and DNA damage response: implications for cancer treatment. Mol. Cancer 18, 169 (2019). CAS PubMed PubMed Central Google Scholar Liu, H. et al. Nuclear cGAS suppresses DNA repair and promotes tumorigenesis. Nature 563, 131–136 (2018)....
Paired uCrCl and eGFR determinations from 470 cisplatin cycles from 121 patients were analyzed [median age: 55 years; most frequent tumor site: genitourinary (45%); palliative treatment: n = 41 (34%)]. Primary endpoint was the proportion of cycles with uCrCl < 50 ml/min/1.73m2 ...
f. Even if the treatment prolongs life, it comes with a great cost in terms of side effects and money. Decide, if the extra time of being alive (but ended up being a vegetable) is worth it? g. Ask about the side effects of the treatment. Very often the “bad effects” are toned ...
oxidative DNA damage that blocks cancer cell division and growth. When used in a conventional manner, doxorubicin will generate cardiotoxic effects, and it has been shown that encapsulated doxorubicin in liposomes helps to overcome the treatment-associated toxicity, showing reduced cardiac toxicity [129...
effects in liver cancer in preliminary studies (22-24). However, as with almost all therapeutics, PD-1/PD-L1 immunotherapy may inevitably cause patients to exhibit varying degrees of immune-related damage. A phase II clinical trial calculated that the probability of treatment-related adverse ...
Dr. Gerson noted some remarkable effects of this procedure including patients no longer needing pain-killers once on the enemas. The Gerson Institute continues to this day to provide Gerson Therapy. NOTE: This treatment is controversial to say the least, and we mention it here only for those ...
Herbal treatment often aims for this target. The first aim of healthy living is to eat and live healthy. Second we should focus on preventing disease. And, lastly if we do get ill, we should try for a whole body cure.Fortunately there is a remedy for all the three stages. Let's ...
of severe side effects, which has been granted breakthrough therapy designation by FDA.98Related studies have shown that although patients experience relapse post-vaccination, lesion progression can be controlled using ICI, suggesting a synergistic effect between neoantigen vaccination and ICI treatment. ...
Systemic effects of local radiotherapy. Lancet Oncol. 10, 718–726 (2009). Article PubMed PubMed Central Google Scholar Finkelstein, S. E. et al. Combination of external beam radiotherapy (EBRT) with intratumoral injection of dendritic cells as neo-adjuvant treatment of high-risk soft tissue ...