Among the goals of patient-centric care are the advancement of effective personalized treatment, while minimizing toxicity. The phase 2 I-SPY2.2 trial uses a neoadjuvant sequential therapy approach in breast cancer to further these goals, testing promising new agents while optimizing individual outcomes...
Stomatitis was the most common side effect in block A. No patients receiving block A treatment alone had adrenal insufficiency. Dato-DXd/durvalumab is a promising therapy combination that can eliminate standard chemotherapy in many patients, particularly the immune-positive subtype. ClinicalTrials.gov ...
Lung cancer is the leading cause of death from cancer in males. Adequate staging is essential if proper treatment is to be administered. Current morphological imaging modalities are confronted with problems in the staging of lung cancer, in the evaluation of treatment response, and in establishing ...
Personalized treatment matching targeted drugs to a tumor’s genetics has resulted in remarkable responses. Unfortunately, most patients’ tumors develop resistance leading to disease relapse. There are multiple mechanisms that may lead to drug resistance1that include genetic and non-genetic heterogeneity ...
Significance levels for entry and retention in the Cox proportional hazard model were 0.1 (10%). The SAS statistical package version 6 (SAS Institute, Raleigh, NC) was used for the statistical evaluation on a Digital MicroVAX computer (Compac, Houston, Tex). The accepted level of significance...
(a) Targeting the cell cycle in the treatment of cancer. (b) Cell-based high-throughput screening (HTS) of 79 827 drug-like molecules for cell cycle modulators. Twenty hours post compound treatment, HeLa cancer cells were fixed and stained with Vybrant DyeCycle green, and a high-content...
which do not choose among the four genetic testing strategies, but do recommend genetic testing in newly diagnosed colorectal cancer.7 The trend seems to be moving toward genetic testing earlier in the diagnostic process to guide treatment and to identify others in families who might be at risk ...
Hypoxia imaging may improve identification of cervical cancer patients at risk of treatment failure and be utilized in treatment planning and monitoring, b
Stomatitis was the most common side effect in block A. No patients receiving block A treatment alone had adrenal insufficiency. Dato-DXd/durvalumab is a promising therapy combination that can eliminate standard chemotherapy in many patients, particularly the immune-positive subtype. ClinicalTrials.gov ...
Educational professionals, including students, need to have access to up-to-date information on best practice skills related to cancer disparities, diagnosis, treatment, and survivorship care. Professionals working in the field of education are in need of new knowledge with a focus on innovative deli...