Our integrated single-cell analysis provides a comprehensive understanding of the tumor heterogeneity in tamoxifen resistance. We envision this integrated single-cell epigenomic and transcriptomic measure will become a powerful approach to unravel how epigenetic factors and the tumor microenvironment govern the...
(2014), this study uses the DepMap data to identify SMARCA2 as a synthetic lethal target in cancer cells deficient for SMARCA4, representing one of the first examples of synthetic lethal relationships unravelled by the DepMap. Article PubMed PubMed Central Google Scholar Chan, E. M. et al....
This phenomenon, now known as the "Warburg effect," is the foundation of one of the earliest general concepts of cancer: that a fundamental disturbance of cellular metabolic activity is at the root of tumor formation and growth. In the ensuing decades, as it became apparent that abnormalities ...
To unravel the mystery, Eindhoven University of Technology researchers used machine learning. They developed a model to predict whether immunotherapy will be effective for a patient using a simple trick. Even better, the model outperforms conventional clinical approaches. The outcomes of this research ...
Although endometrial cancer management remains challenging, a deeper understanding of the genetic diversity as well as the drivers of the various pathogenic states of this disease has led to development of divergent management approaches in an effort to improve therapeutic precision in this complex malign...
(NK) cells, and macrophages require energy to mount effective immune responses against cancer cells [18,19]. However, within the TME, the availability of nutrients, including glutamine, is limited due to competition among diverse cell populations [20]. Figure1B shows the metabolic competition ...
To unravel the mystery, Eindhoven University of Technology researchers used machine learning. They developed a model to predict whether immunotherapy will be effective for a patient using a simple trick. Even better, the model outperforms conventional clinical approaches. The outcomes of this research ...
The molecular biology of TNFR2 The genomic organization of the TNFRSF1B gene Decades ago, considerable efforts were made to unravel the genetic, structural, and mechanistic importance of human TNFR1 and TNFR2. In this respect, theTNFRSF1AandTNF-αgenes are located on chromosomes 12p13, and ...
Both the gut and the tumour microbiome are now established as crucial regulators of cancer phenotypes and have been implicated in cancer initiation, progression and therapy response. Although the role of bacteria in these processes is beginning to be unravelled, the relevance of fungi is only just...
Moreover, cancer cell intrinsic processes like oncogene-driven metabolic reprogramming, perturbations in mitochondrial homeostasis, autophagy, viral response-like gene signature and their link with danger signalling needs to be completely unravelled. Conflict of Interest The authors declare no conflict of ...