Surgical resection of tumours often requires blood transfusion. In case of a curative operation, the primary tumour is removed, but nevertheless a percentage of the patients will develop distant metastases [7]. Minimal residual disease in the form of undetectable micrometastases and/or tumour cells ...
In most cancers, germline and stem cells, long-term proliferation requires telomerase activity to overcome the telomere shortening, which occurs with cell division. This shortening eventually arrests cellular growth, potentially providing an initial proliferative barrier to tumor formation in humans [5]. ...
Decreased production of blood cells due to toxic drug side effects. This can result in anaemia that requires red-blood-cell transfusion, increased susceptibility to infections due to low numbers of leukocytes and increased bleeding propensity due to insufficient numbers of platelets. AUTOLOGOUS TRANSPLANT...
The CRISPR system is a revolutionary genome editing tool that has the potential to revolutionize the field of cancer research and therapy. The ability to precisely target and edit specific genetic mutations that drive the growth and spread of tumors has opened up new possibilities for the developmen...
G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood. Immunity 17, 413–423 (2002). Article CAS PubMed Google Scholar Serbina, N. V. & Pamer, E. G. Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine...
4 In cirrhotic patients, perioperative mortality and blood transfusion requirements should not exceed 2–3% and 10%, respectively.454., 55., 56., 57. This requires careful selection of candidates to avoid life-threatening surgery-related complications and necessitates an adequate assessment of liver...
For all skin cancers, optimal patient management requires a multidisciplinary approach including dermatology, medical oncology, and radiation oncology. Keywords: malignant melanoma; non-melanocytic skin cancer; cutaneous lymphoma1. Introduction In recent years dermato-oncology has had important developments ...
Maintaining comparable benefits and harms of screening with cytology alone or hrHPV testing alone requires that patients, clinicians, and health care organizations adhere to currently recommended protocols for repeat testing, diagnostic colposcopy, and treatment.6,7 Timing of Screening Women Younger Than ...
Solving these problems requires the assembly of highly skilled, multidisciplinary teams working collaboratively employing many of the development strategies being discussed for lung cancer screening research. OTHER APPLICATIONS OF QUANTITATIVE IMAGING IN LUNG CANCER MANAGEMENT The evolution of lung cancer ...
Fujii S, Liu K, Smith C, Bonito AJ, Steinman RM (2004) The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation. J Exp Med 199(12):1607–1618 Article CAS PubMed PubMed Central Googl...