synthesized an octaarginine (RRRRRRRR)-oxaliplatin conjugate through a specific heterobifunctional linker, which can quickly and successfully deliver oxaliplatin to colon cancer cells, showing quite high resistance tumor activity.233 In addition to targeting peptides and cell penetrating peptides, some biol...
This study showed that IDH mutations lead to a gain-of-function activity, thus suggesting that this enzyme could be a therapeutic target. Article CAS PubMed PubMed Central Google Scholar Ward, P. S. et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic ...
Studies indicate that physical activity can protect against breast, colon, or prostate cancer, for example. Sedentary lifestyle as a risk factor Exercise is fun and keeps you healthy Exercise and exercise can lower your risk of cancer. To be physically active and you will experience that you ...
Tumor cells expressing these lesions failed to upregulate MHC class I pathway activity when exposed to IFN-γ. Similar lesions were found in other studies that reported deficiencies of IFN receptor signaling pathway components in prostate cancer (G.P.D. and R.D.S., unpublished data) and ...
trans-differentiation path from DGC to NEC, immune evasion was gradually increased with decreasing interferon pathway response activity in malignant cells, though this finding needs further functional investigation. Metabolic reprogramming Metabolic reprogramming, also known as deregulated cellular metabolism, ...
and EMT toward tumor progression and invasion. CSCs also derived PD-L1 mediate the infiltration of Tregs. An additional layer of regulation of T cell activity is mediated indirectly by immunosuppressive myeloid cells, including macrophages and monocytic myeloid-derived suppressor cells (M-MDSCs). This...
modified delivery systems have aimed at distribution and selective accumulation of drug molecules at receptor sites resulting in constant maintenance of high drug bioavailability for effective anti-tumour activity. In this review, we highlighted the state-of-the art viral and non-viral drug and gene ...
walking. Believe it or not, but take the research findings that your brain receives a thorough workout while you walk. It happens because during walking you have to navigate your movement throughout different terrains. The more challenging a terrain, the more workout activity you supply to ...
et al. A natural polyphenol exerts antitumor activity and circumvents anti-PD-1 resistance through effects on the gut microbiota. Cancer Discov. 12, 1070–1087 (2022). Article CAS PubMed PubMed Central Google Scholar Huang, J. et al. Ginseng polysaccharides alter the gut microbiota and ...
Anti-adhesive agents (termed here as “cell surfactants” or “cancer metastasis chemopreventive agents”) constitute a group of substances with pharmacological activity that can specifically inhibit the contact/adhesion process between heterogeneous cells induced by various bioactive substances (such as infl...