Here, we show that type I interferons (IFNs-I) function as molecular hubs of resistance during immunogenic chemotherapy, triggering the epigenetic regulator demethylase 1B (KDM1B) to promote an adaptive, yet reversible, transcriptional rewiring of cancer cells towards stemness and immune escape. ...
These molecules have therapeutic potential in promoting tissue regeneration, supporting stem cell activity, preventing cell death, modulating immune responses, and promoting the growth of new blood vessels. However, the precise roles of exosomes derived from mesenchymal stem cells (MSCs) in the ...
Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion. Nat. Rev. Cancer 21, 298–312 (2021). Article CAS PubMed Google Scholar Krysko, D. V. et al. Immunogenic cell death and DAMPs in cancer therapy. Nat. Rev. Cancer 12, 860–875 (2012). Article CAS ...
m6A methylation: a process reshaping the tumour immune microenvironment and regulating immune evasion. January 01, 2023 [MEDLINE Abstract] LncRNA-BC069792 suppresses tumor progression by targeting KCNQ4 in breast cancer. January 01, 2023 [MEDLINE Abstract] ...
Cancer stem cells (CSCs) are a sub-population of tumour cells, which are responsible to drive tumour growth, metastasis and therapy resistance. It has recently been proposed that enhanced glucose metabolism and immune evasion by tumour cells are linked, and are modulated by the changing tumour mi...
Additionally, this method enables the monitoring of rare cell mutations during processes of tumor occurrence and development, such as the acquisition of invasive and metastatic abilities, as well as the infiltration and activation of immune cells and other important processes [30]. scRNA-seq can ...
(NEM) relay (mechanical transistor) by the electric current, and it could break the chamber ceiling, exposing a drug identified by the immune system for cell elimination. This concept is in line with the effort on designing an autonomous computational nanorobot for in vivo medical diagnosis and ...
cell surface composition as well as the leak of signaling molecules. These signals enhance the tumor antigen presentation to T lymphocytes by triggering a set of receptors expressed by dendritic cells (DCs). In fact, ICD is a key mechanism for stimulating the immune cells against tumor cells [...
Cancer stemness, referring to the stem-cell-like phenotype of cancer cells, has been recognised to play important roles in different aspects of hepatocarcinogenesis. A number of well-established cell-surface markers already exist for liver cancer stem ce
Therapeutic cancer vaccines have undergone a resurgence in the past decade. A better understanding of the breadth of tumour-associated antigens, the native immune response and development of novel technologies for antigen delivery has facilitated improve