Which cancer screenings work? Testing advances give more choices, but may offer false positivesAMY DOCKSER MARCUS
摘要: BACKGROUNDFalse-positive cancer screenings may affect a patient’s willingness to obtain future screening.关键词: False Positive Reactions, Cancer Screening, Cancer Screening Tests, Early Detection of Cancer, Mass Screening, Diagnostic Errors ...
False Positives/Negatives:Screenings, especially mammograms, can sometimes produce false positives, leading to unnecessary stress and procedures, or false negatives, missing cancer when it is present. Radiation Exposure:Though low, there's a risk of radiation exposure with mammograms. Overdiagnosis:Screen...
Also, in the US, false positives are disturbingly common, with about 11% of women receiving a false-positive result from a single screening,2In Europe, cases are far lower at 2.5%, but this still corresponds to a large cumulative risk ...
False positives aren’t uncommon in lung cancer screenings, particularly in initial scans. However, as you continue to get screened yearly, false positives are less likely because doctors can compare each new scan to the last for changes. The rate of false positives in lung cancer screening is...
1.4 Overdiagnosis The major harm of screening considered by the panel was that of overdiagnosis. Given the definition of an overdiagnosed cancer, either invasive or non-invasive, as one diagnosed by screening, which would not otherwise have come to attention in the woman's lifetime, there is ...
Since even a highly selective assay used in a population screening still could generate a large number of false positives, when millions of individuals are screened for presence of cancer, it is particularly important to rule out false positives, which could cause considerable and unnecessary stress...
To our surprise, AKT gene knockdowns did not reciprocate the effect seen with AKT inhibitors in the MFM-223 cell line. This result suggests that a compound screening approach yields more directly translatable result than loss-of-expression screenings. Download: Download high-res image (676KB) ...
false-positive (TP:FP) ratio; and the cost of diagnostic investigations among screen positives, per cancer detected (Diagcost). Outcomes were estimated for recommended screening only, and then when giving the MCED test to anyone without cancer detected by current screening plus similarly aged ...
Tanimoto similarity cutoff of 0.35, the Butina clustering algorithm [38], and extended connectivity fingerprints with up to four bonds. Drug-like properties were also used to filter the results and exclude likely false positives, such as aggregators, autofluorescent molecules, and pan-assay ...