Research Highlight | 16 October 2024 Perioperative immunotherapy for bladder cancer In the NIAGARA trial, the addition of perioperative durvalumab to standard treatment for muscle-invasive bladder cancer improved event-free and overall survival, marking a new treatment option for this condition. Karen...
Cancer is one of the most devastating and haunting diseases, affecting the lives of millions around the globe[3]. Despite the immense efforts involved in cancer research, prevention, detection, and treatment, the number of cancer cases has continued to increase[1, 4]. ...
The protective role of FA is well established in colorectal cancer, and the underlyingepigenetic mechanismhas also been extensively characterized. Such studies have not been conducted in prostate cancer. Recent research demonstrated that similar protection could be obtained in prostate cancer....
Despite over 100 years of research, the success of therapeutic cancer vaccines has been variable, particularly in advanced cancer patients, with various limitations, including the heterogeneity of the tumor microenvironment, the presence of immunosuppressive cells, and the potential for tumor escape ...
What still stands out, particularly, is that some of the contributing cancer research centers started looking into using the body’s immunity. This was made in the mid-1970’s. What happened, is that the drug companies cracked down. Because upper level Cancer Institute bureaucrats were “in ...
We are interested in research that investigates and characterizes metabolic alterations in tumors at the molecular level by explaining why this reprogramming occurs and identifying links between such phenomena and cell proliferation and metastasis. We will also consider studies regarding the correlation betwe...
et al. Microbiota-derived short-chain fatty acids promote the memory potential of antigen-activated CD8+ T cells. Immunity 51, 285–297 e285 (2019). This study shows that microbiota-derived metabolites, SCFAs, can guide the metabolic rewiring that increases the memory potential of antigen-...
(CTC), Computational Biology/Systems and Bioinformatics, Conference Coverage with Social Media, Liquid Biopsy Chip detects an array of metastatic cancer cell markers in blood, Personalized and Precision Medicine & Genomic Research, Precision Cancer Medicine, R...
If memory serves, I think it was on the front page of The New York Times, the same day as plenary in 2022. I know for a fact that my friends and family who are not in medicine knew about it roughly the same time I did. It was a big news story. Dr. Cercek herself ha...
Clonal evolution is now a central theoretical framework in cancer research. In this Perspective, Laplane and Maley identify challenges to that theory such that some non-evolutionary phenomena in cancer cannot be captured by the theory. They also outline how other challenges, including non-genetic he...