the addition of just a few cancer cases to one curve earlier than to the other curve has to cause very high Relative Risks --- even when the higher rates are not very high at all. Such events are illustrated for
Multiple myeloma (MM) is a hematopoietic malignancy of terminally differentiated plasma cells (PC) [1]. Multiple myeloma comprises 1.5% of all malignant diseases and accounts for 10% of all hematologic malignancies [2]. Despite the advent of novel therapies, MM remains difficult to treat and con...
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Disclosed herein are chimeric antigen receptor (CAR) polypeptides, which can be used with adoptive cell transfer to target and kill cancers, that comprise a co-stimulatory signaling region having a mutated form of a cytoplasmic domain of CD28 that enhances CAR-T cell function, a mutated form of...
Disclosed herein are chimeric antigen receptor (CAR) polypeptides, which can be used with adoptive cell transfer to target and kill cancers, that comprise a co-stimulatory signaling region having a mutated form of a cytoplasmic domain of CD28 that enhances CAR-T cell function, e.g. by reducing...
Researchers at the University of Michigan Health System have found a new indicator that may predict which patients with a common type of throat cancer are most likely have the cancer spread to other parts of their bodies.