Obesity is associated with aggressive prostate cancer. To explore whether weight loss favourably affects tumour biology and other outcomes, we undertook a presurgical trial among overweight and obese men with prostate cancer. This single-blinded, two-arm
a Survival curve for VillinCreER Apcfl/+ and VillinCreER Apcfl/+ Bcl9fl/fl Bcl9lfl/fl mice aged until clinical end-point, n = 16 for VillinCreER Apcfl/+ (3 censors—1 mouse had lymphoma, 1 with elongated teeth and another displayed rapid weight loss without significant tumour ...
Unsurprisingly, the factors required for passive metastasis in the peritoneal cavity are very different from those necessary for hematogenous spread, where tumor cells are exposed to the hydrodynamic forces present during rapid transport through the blood vessels [21]. In fact, Nishimori et al. [42,...
but not p53 mutation, is associated with reduced overall survival and more rapid disease progression in RCC [135]. However, in our view the question is whether the increased p53 expression in RCC tissues is actually mutant
Strategizing the drug delivery system to a level that shows no toxic reactions, rapid uptake and improved cellular inhibition assists in cell death. Nanoparticles should have a size greater than 10 nm and should be about 100 nm to avoid renal filtration and specific liver uptake, respectively. ...
The presence of DNA damage either by exogenous or endogenous agents triggers the functional mechanisms of DDR leading to the rapid and efficient repair of DNA damage through cell cycle arrest and delays, and in some cases, apoptosis of cells when DNA damages accumulate beyond repair. This ...
Natural selection operates on the basis of the adaptive benefit to individual cells in the lineage of more rapid cell division or higher resistance to cell death (apoptosis) than occurs in neighboring cells. Most of the random mutations and epimutations that arise during progression to cancer are...
In recent years, with the rapid development of artificial intelligence, artificial intelligence algorithms have been widely used in the medical field. Deep learning, as one of artificial intelligence algorithms, is a machine learning method based on deep neural networks [21,22]. Deep learning is wi...
whereas those treated with STEAP1-mBBζ CAR T cells uniformly exhibited rapid disease regression which was followed by subsequent relapse ten days later (Supplementary Fig.12b, c). STEAP1-mBBζ CAR T cell therapy was associated with a statistically significant survival benefit (22 days versus 12...
and Use Committee at the University of Pennsylvania and all methods were performed in accordance with the relevant guidelines and regulations. Mice were purchased at 4–6 weeks of age. Weight was measured on arrival and monitored biweekly. Mice were euthanized in the event of rapid weight loss....