Posttranslational modifications (PTMs) of proteins, the major mechanism of protein function regulation, play important roles in regulating a variety of cellular physiological and pathological processes. Although the classical PTMs, such as phosphorylation, acetylation, ubiquitination and methylation, have be...
Here, we show that inhibitors of the KIF18A motor protein activate the mitotic checkpoint and selectively kill chromosomally unstable cancer cells. Sensitivity to KIF18A inhibition is enriched in TP53-mutant HGSOC and TNBC cell lines with CIN features, including in a subset of CCNE1-amplified, ...
Genes and molecular mechanism of the circadian clock in mammals In mammals, the circadian system is an integral regulatory system composed of a master clock and peripheral clocks. The master clock exists in the suprachiasmatic nucleus (SCN) of the brain, whereas the peripheral clocks reside in per...
The objective of this study was to explore the perceptions and opinions towards brain cancer related to cell phone use among university students in Malaysia. The study revealed that the majority of the study participants believe that there is no relationship between brain cancer and hand phone use...
CONCLUSION: Neratinib plus capecitabine is active against refractory, HER2-positive breast cancer brain metastases, adding additional evidence that the efficacy of HER2-directed therapy in the brain is enhanced by chemotherapy. For optimal tolerance, efforts to minimize diarrhea are warranted. ...
Growing concern has arisen from the quasi-exponential increase in the numbers and quantities of man-made chemicals that presently are in current use, and their potential effects on human health, especially their delayed effects on degenerative diseases s
The expression of CD133 is not restricted to normal stem cell, but also found in many tumor types. Dirks et al. discovered that CD133 expressed in brain tumors and used CD133 as a CSC marker to identify brain CSCs [9]. CD133 was also identified in various other tumors including breast...
leukemia (blood cancer), Burkitt lymphoma (a fast-growing lymph gland cancer), Hodgkin lymphoma (a lymph gland cancer), Retinoblastoma (a childhood eye cancer), Wilms tumor (a childhood kidney cancer), and low-grade glioma (a brain cancer). These represent 50-60 percent of all childhood ...
Removal of introns from messenger RNA precursors (pre-mRNA splicing) is an essential step for the expression of most eukaryotic genes. Alternative splicing enables the regulated generation of multiple mRNA and protein products from a single gene. Cancer cells have general as well as cancer type-spe...
J. It takes nerve to fight back: the significance of neural innervation of the bone marrow and spleen for immune function. Semin. Cell Dev. Biol. 61, 60–70 (2017). Article CAS PubMed Google Scholar Zhang, X. et al. Brain control of humoral immune responses amenable to behavioural ...