Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their
Information on the causes of death were determined by death certificates and coded using the International Classification of Diseases 10th revision (ICD-10). The primary endpoint was total cancer deaths (C00–C97), and secondary outcomes were lung (C33–34), stomach (C16), colon (C18), rectum...
Because of the well-recognized phenomenon of “field cancerization” in the head and neck region, persons with primary tumors of the oral cavity and pharynx are also more likely to develop cancers of the esophagus, larynx, lung, and stomach. In addition, those with oral cancer often have ...
The five types of cancer were cho- sen on basis of the highest incidence in the population (breast, prostate, lung, and colon) and the highest rate of judicialization (all the above plus brain cancer) [39]. Cancer cases were identified by ICD-10 C50 – Malig- nant Neoplasm of Breast...
et al. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med. 1996;334:1150-11558602180Google ScholarCrossref 32. Bjelakovic G, Nikolova D, Simonetti RG, Gluud C. Antioxidant supplements for prevention of gastrointestinal cancers: a ...
Human trophoblastic cell surface antigen 2 (Trop2) is a glycoprotein, a cellular marker of trophoblastic and stem cells, and a calcium signaling transducer involved in several signaling pathways, leading to the proliferation, invasion, and metastasis of
If <40 years of age, the plurality of heart disease deaths occurs in patients treated for breast cancer and lymphomas; if ≥40, from cancers of the prostate, colorectum, breast, and lung. For almost all cancer survivors, the risk of fatal heart disease increases with time. These findings...
Incidence rate ratios (IRR) subdivided by type of ICD-10 child psychiatric disorders in offspring to parents with lung cancer, adjusted for sex, age, and calendar period, Denmark, 1994-2011.Michael, Eriksen Benro...
Immunogenic cell death (ICD) offers a potential approach to improving the efficacy of cancer therapy. It is a functionally distinct response pathway that involves the development of cellular stress, followed by cell death and the release of a variety of DAMPs [4]. In fact, ICD promotes the de...
Courtright K, Manaker S. Counterpoint: should lung cancer screening by chest CT scan be a covered benefit? no. Chest. 2015;147(2):289-292. doi:10.1378/chest.14-2815PubMedGoogle ScholarCrossref 19. Kinsinger LS, Anderson C, Kim J, et al. Implementation of lung cancer screening in the...